Results 111 to 120 of about 5,285,111 (395)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluation of the Consequences and Costs of the Anglo-American System in the Pre-Hospital Emergency Department of Yazd in 2018

Journal of Evidence Based Health Policy, Management & Economics, 2023
Background: One of the most important tasks of health care managers is  allocateing resources, controling them and ensuring their effective use when available. This study examines the consequences and costs of emergency services in Yazd in 2018. Methods:
Mohsen Pakdaman, Roohollah Askari, Ahmad Dehghan, Saeedreza Pahlavanpoor, Alireza Nikafshan   +4 more
doaj  

The Use of Simulation in Pre-doctoral Medical Emergencies Training [PDF]

, 2014
poster abstractObjective: This purpose of this study was to determine the level and method of teaching medical emergencies management in U.S. pre-doctoral programs, particularly the extent to which patient simulation techniques are employed for ...
Bennett, Jeffrey, Romito, Laura M., Vajda, Derek   +2 more
core  

Using Technology to Enhance Rural Resilience in Pre-hospital Emergencies [PDF]

, 2015
The research presented in this paper is supported by RCUK dot.rural Digital Economy Research Hub, University of Aberdeen [grant number EP/G066051/1].Peer reviewedPublisher ...
Kindness, Peter, Mellish, Chris, Mort, Alasdair, Reiter, Ehud, Schneider, Anne Helen, Wilson, Philip   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Morbidity and mortality profile of patients seen in medical emergency unit of a Teaching Hospital in Nigeria: A 4-year audit

Sahel Medical Journal, 2018
Background: Ahmadu Bello University Teaching Hospital (ABUTH) Zaria is strategically located to serve as referral center for most stable and emergency cases in the northwestern part of Nigeria. Patients also come on self-referral.
Bello Yusuf Jamoh, Sani Atta Abubakar, Sani Muhammad Isa   +2 more
doaj   +1 more source

Addressing the challenges of ECMO simulation [PDF]

, 2018
This document is the Accepted Manuscript. The final, definitive version of this paper has been published in Perfusion, May 2018, published by SAGE Publishing, All rights reserved.Introduction/Aim: The patient’s condition and high-risk nature of ...
Ait Hssain, Ali, Al Disi, Mohammed, Alhomsi, Yahya, Alinier, Guillaume, Alsalemi, Abdullah, Amira, Abbes, Bensaali, Faycal, Fawzy Hassan, Ibrahim, Ibrahim, Abdul Salam Saif, Labib, Ahmed   +9 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

In-Flight Medical Emergencies

Cambridge International Law Journal, 2018
n engl j med 374;3 nejm.org January 21, 2016 291 type of intravenous fluid can result in fluid overload if administered in excessive quantities (for example, in patients with end-stage renal disease or heart failure in whom both sodium excretion and ...
J. Nable
semanticscholar   +1 more source