Results 41 to 50 of about 5,748,439 (360)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Chinese emergency expert consensus on the diagnosis and treatment of sepsis-associated encephalopathy in the elderly

Journal of Acute Disease
Sepsis-associated encephalopathy (SAE) is a diffuse dysfunction of the nervous system resulting from sepsis originating outside the central nervous system.
Wei Gu, Jie Zhong, Yongli Han, Yuxiang Liu, Chuanzhu Lv, Guoqiang Zhang, Miaorong Xie, Yuefeng Ma, Wei Guo, Society of Emergency Medicine of Chinese Medical Association, Emergency Medicine Branch of Chinese Geriatrics Society and Emergency Medicine Branch of Beijing Medical Association   +9 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Acne fulminans – medical emergency in the practice of the family doctor [PDF]

Romanian Journal of Medical Practice, 2017
Acne is a common affection in the family doctor's office, usually treating light acne forms. It is very important to detect acne fulminans as soon as possible.
Ana Maria Alexandra STĂNESCU, Ioana Veronica GRĂJDEANU, Ana Maria GOANŢĂ, Călin GIURCĂNEANU   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Telemedicine: A force multiplier of combat medical care in the Indian Navy

Journal of Marine Medical Society, 2019
The tasking of the Indian Navy has increased manifolds in the recent past due to the country's growing economic importance, increasing energy requirements, and expanding trade routes. As operational elements of the blue water Navy, Indian Naval ships and
Saurabh Bobdey, Shankar Narayan, M Ilankumaran, G Vishwanath, M V Singh, A K Sinha, N Anand, Kiran Maramraj   +7 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Writing a textbook on emergency medicine - my experience

Saudi Journal of Emergency Medicine
Writing a Textbook on Emergency Medicine -My Experience [SJEMed 2022; 3(3.000): 180-180]
Devendra Richhariya
doaj   +1 more source

Consultation-liaison psychiatry services: Difference in the patient profile while following different service models in the medical emergency

Indian Journal of Psychiatry, 2015
Aim: To compare “consultation” and “hybrid” models of consultation-liaison (CL) services provided to patients visiting the medical emergency outpatient services.
S. Grover, S. Sarkar, A. Avasthi, S. Malhotra, A. Bhalla, Subhash Varma   +5 more
semanticscholar   +1 more source