Results 241 to 250 of about 9,201,948 (316)

Incorporating correctional medicine exposure into pre-health education: a program description. [PDF]

Int J Med Educ
Herrera Vargas S, Jansen SL, Romano M, Coatsworth E, Chiang H, Handler E, Watson J, Taraman S.   +7 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Estrogen receptor-dependent mechanisms underlying DES promoted endometrial carcinoma: Study in vivo. [PDF]

Eur J Obstet Gynecol Reprod Biol X
Waluyo ST, Tjopkroprawiro BA, Wang PH, Widjiati W.   +3 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Disease Progression in Iatrogenic Cerebral Amyloid Angiopathy. [PDF]

Neurology
Fandler-Höfler S, Storti B, Kaushik K, Panteleienko L, Pikija S, Rossini F, Damavandi PT, Canavero I, Negro G, DiFrancesco JC, Enzinger C, Gattringer T, Van Etten ES, Bersano A, Wermer MJH, Banerjee G, Werring DJ.   +16 more
europepmc   +1 more source

Modeling Exposure-Mortality Relationships for Indoor Heat. [PDF]

Risk Anal
Ibbetson A, Simpson C, Petrou G, Oikonomou E, Mavrogianni A, Gupta R, Davies M, Milojevic A.   +7 more
europepmc   +1 more source

Brain Gadolinium Biodistribution, Clearance, and Retention Following High-Dose Contrast-Agent Exposure in Mice: A Multimodal Study. [PDF]

Toxics
Zahavi A, Richard S, Girshevitz O, Obied B, Vardizer Y, Kreizman-Shefer H, Bajar J, Luckman J, Fixler D, Goldenberg-Cohen N.   +9 more
europepmc   +1 more source