Results 151 to 160 of about 10,185,878 (314)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Minutes: Medical School Faculty Advisory Council, Dec. 2, 2003

, 2003
Faculty advisory council to the Dean of the Medical School.University of Minnesota. Medical School Faculty Advisory Council. (2003). Minutes: Medical School Faculty Advisory Council, Dec. 2, 2003. Retrieved from the University Digital Conservancy, https:/
University of Minnesota. Medical School Faculty Advisory Council
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Minutes: Medical School Faculty Advisory Council, April 6, 2004

, 2004
Faculty advisory council to the Dean of the Medical School.University of Minnesota. Medical School Faculty Advisory Council. (2004). Minutes: Medical School Faculty Advisory Council, April 6, 2004. Retrieved from the University Digital Conservancy, https:
University of Minnesota. Medical School Faculty Advisory Council
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Minutes: Medical School Faculty Advisory Council, Nov. 6, 2007

, 2007
Faculty advisory council to the Dean of the Medical School.University of Minnesota. Medical School Faculty Advisory Council. (2007). Minutes: Medical School Faculty Advisory Council, Nov. 6, 2007. Retrieved from the University Digital Conservancy, https:/
University of Minnesota. Medical School Faculty Advisory Council
core  

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Minutes: Medical School Faculty Advisory Council, Feb. 5, 2008

, 2008
Faculty advisory council to the Dean of the Medical School.University of Minnesota. Medical School Faculty Advisory Council. (2008). Minutes: Medical School Faculty Advisory Council, Feb. 5, 2008. Retrieved from the University Digital Conservancy, https:/
University of Minnesota. Medical School Faculty Advisory Council
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Perceptions of medical faculty on an e-learning module providing faculty development. [PDF]

Spartan Med Res J
Figg BJ, Hicks T, Santen SA, Bihn C, Vance S, Wagner MJ.   +5 more
europepmc   +1 more source