Results 91 to 100 of about 21,447 (247)

Marked variation in eligibility criteria across registrational trials for relapsed diffuse large B‐cell lymphoma limits applicability to clinical practice

British Journal of Haematology, EarlyView.
Summary Therapeutic options for relapsed or refractory diffuse large B‐cell lymphoma (rDLBCL) have expanded following accelerated approvals based largely on surrogate end‐points, yet confirmatory studies have not consistently reproduced these benefits across all agents, and outcomes for many patients remain poor.
Elizabeth Goodall, Jodie Palmer, Arina Martynchyk, Niamh Waters, Fiona Swain, Tran Binh Giang, Tamara Marconi, Jamie Brennan, Gareth P. Gregory, Chan Cheah, Colm Keane, Eliza A. Hawkes   +11 more
wiley   +1 more source

Limitação terapêutica para crianças portadoras de malformações cerebrais graves

Revista Bioética
Resumo As malformações cerebrais congênitas podem se apresentar de forma leve ou grave, podendo ser letais mesmo poucas horas após o nascimento. A partir de levantamento bibliográfico sistemático, verificou-se que, embora em tese sejam eticamente ...
Dario Palhares, Íris Almeida dos Santos, Antônio Carlos Rodrigues da Cunha   +2 more
doaj   +1 more source

A Multi-Stage Drop-the-Loser Design With Superiority Boundaries. [PDF]

Stat Med
ABSTRACT Multi‐arm multi‐stage (MAMS) trials have gained popularity, due to their improved efficiency in evaluating multiple treatments. A traditional MAMS trial often decreases the expected sample size of the trial compared with just running a multi‐arm approach, but with the drawback of an increase in maximum sample size.
Greenstreet P, Khan M, Kanji S, Motazedian P, Seely A, Sibley S, Ramsay T.   +6 more
europepmc   +2 more sources

Oligoprogressive renal cell carcinoma: What is the role of surgery?

BJU International, EarlyView.
Objective To provide an overview of the biological mechanism and pattern of oligoprogression in renal cell carcinoma (RCC) and the most updated role of surgery in this setting, highlighting scientific gaps and informing future implications. Methods A non‐systematic search of PubMed/MEDLINE was performed in August 2025 including guidelines, reviews, and
Chiara Re, William H.J. Ince, Leo Bickley, James P. Blackmur, Mouhamad H. Ismail, Justicia Kyeremeh, Teele Kuusk, Eva Mendes Serrao, James O. Jones, Grant D. Stewart   +9 more
wiley   +1 more source

Distanásia e ortotanásia: práticas médicas sob a visão de um hospital particular

Revista Bioética
Dentre os conceitos relacionados à terminalidade da vida, encontram-se a distanásia e a ortotanásia. Distanásia significa a obstinação terapêutica para adiar a morte iminente.
José Antônio Cordero da Silva, Luis Eduardo Almeida de Souza, Luísa Carvalho Silva, Renan Kleber Costa Teixeira   +3 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Final Analysis of Neoadjuvant Sintilimab Plus Chemotherapy in IB–IIIA Non‐Small‐Cell Lung Cancer: Phase 2 neoSCORE Trial

Cancer Science, EarlyView.
Kaplan–Meier survival curves comparing two‐cycle versus three‐cycle neoadjuvant sintilimab plus chemotherapy. (A) Disease‐free survival (DFS). (B) Overall survival (OS). CI, confidence interval; HR, hazard ratio; NR, not reached. ABSTRACT The optimal number of neoadjuvant chemoimmunotherapy cycles for resectable non‐small cell lung cancer (NSCLC ...
Miner Shao, Jie Yao, Lufeng Zhao, Ling Zhu, Baizhou Li, Lili Li, Bangyi Zhou, Yixin Zhang, Huiying Liu, Xiaoke Chen, Zuqun Wu, Zexin Chen, Junqiang Fan, Fuming Qiu   +13 more
wiley   +1 more source

Quality and Consistency of Penicillin Allergy Delabelling Guidelines: A Systematic Review

Clinical &Experimental Allergy, EarlyView.
Eighteen penicillin allergy delabelling guidelines from 12 countries were reviewed. There is consensus for staged risk‐based testing, with emerging support for direct oral challenge in low‐risk patients and expanded non‐specialist roles. Overall guideline quality was low, with major gaps in methodological rigour, stakeholder involvement, and ...
Jessie He, Marina Guirguis, Sankare Devanandan, Rani Scott‐Farmer, Sandra Vale, Michaela Lucas, Jennifer J. Koplin, Catherine J. Hornung, Sandra M. Salter   +8 more
wiley   +1 more source

Parenting Support for Mothers Raised in Out‐Of‐Home Care

Child &Family Social Work, EarlyView.
ABSTRACT Research and social indicators consistently confirm that young people who exit statutory out‐of‐home care (OOHC) tend to remain socially and economically disadvantaged through young adulthood. The present article reports findings from a qualitative study of the perceived parenting support needs of eight mothers (aged 17–30 years) who had spent
Jamie Ussher, Sarah Whitcombe‐Dobbs, Michael Tarren‐Sweeney   +2 more
wiley   +1 more source

Navigating the Activist Techno‐Social Landscape: Washington, DC High School Students' Engagement with Social Media Content

Children &Society, EarlyView.
ABSTRACT In recent decades, youth activism has experienced a global resurgence, playing a pivotal role in advocating for social and political change across diverse national and international contexts. Drawing on empirical data from a study of high school students in diverse Washington, DC public schools, this paper offers a unique perspective on youth ...
Vanessa R. Sperduti, Miri Yemini, Laura Engel, Garth Stahl   +3 more
wiley   +1 more source