Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Adaptive designs in randomized clinical trials: reanalysis of the HOVON87/NMSG18 multiple myeloma trial. [PDF]
EClinicalMedicineSeefat MR +15 more
europepmc +1 more source
Treating age‐related loss of muscle mass and function: Where should we be focusing?
The Journal of Physiology, EarlyView.Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham +4 more
wiley +1 more source
Exploring Bayesian adaptive designs in multi-arm randomized controlled trials with a patient preference arm. [PDF]
J Biopharm StatBrown AR +5 more
europepmc +1 more source
When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart
The Journal of Physiology, EarlyView.Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert +6 more
wiley +1 more source
Competing World Views, Professional Norms, and Conscience. [PDF]
HEC ForumIltis AS.
europepmc +1 more source
Higher Education Quarterly, Volume 80, Issue 3, July 2026.ABSTRACT This paper examines how the taboos and problems perceived by doctoral students are associated with their well‐being and their intentions to persist in or leave academia. We distinguish between doctoral problems—stressors associated with doctoral study—and doctoral taboos, understood as issues that remain difficult to voice in relationships ...
Tomáš Lintner +6 more
wiley +1 more source
Benefits of group sequential design and sample size re-estimation for randomised controlled trials evaluating the prevention of ventilator-associated pneumonia: a simulation study informed by real world data. [PDF]
BMC Med Res MethodolJackson H +4 more
europepmc +1 more source
Australian and New Zealand Journal of Family Therapy, Volume 47, Issue 2, June 2026.ABSTRACT Hoarding disorder is a chronic and disabling disorder that impacts not only the person experiencing the disorder but also their family members. This qualitative study explored the impacts of clinical levels of hoarding on adult children and partners of individuals with hoarding disorder.
Zoe Butt +5 more
wiley +1 more source