Results 21 to 30 of about 73,843 (199)

Attaining Good End-of-Life Care in Intensive Care Units in Taiwan—The Dilemma And the Strategy

International Journal of Gerontology, 2009
One of the major challenges for intensivists is resolving the conflicting interests in end-of-life care. We reviewed patients' characteristics in an intensive care unit to determine the major barriers of practicing good end-of-life care and the medical ...
Shih-Yi Lee, Chung-Lieh Hung, Jun-Hua Lee, Shou-Chuan Shih, Yu-Ling Weng, Wen-Han Chang, Yueh-Hsiu Ho, Wen-Chu Huang, Yuen-Liang Lai   +8 more
doaj   +1 more source

Communication challenges in end-of-life decisions

Swiss Medical Weekly, 2020
With the progress in healthcare over recent decades and a growing life expectancy, discussions and decisions regarding end-of-life issues have become increasingly important. Especially in intensive care and emergency medicine there is a growing need of
Christoph Becker, Katharina Beck, Alessia Vincent, Sabina Hunziker   +3 more
doaj   +1 more source

Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types [PDF]

, 2017
Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor ...
Aftimos, Philippe, Awada, Ahmad, Brayer, Jason B, Catala, Gaetan, Davila, Marco L, Gilham, David E, Hendlisz, Alain, Kerre, Tessa, Lehmann, Frederic F, Lonez, Caroline, Machiels, Jean-Pascal H, Odunsi, Kunle, Piette, Fanny, Sallman, David A, Van den Neste, Eric, Verma, Bikash   +15 more
core   +1 more source

On Charlie Gard: Ethics, Culture, and Religion [PDF]

, 2018
The 2017 story of Charlie Gard is revisited. Upon the British High Court’s ruling in favor of the physicians that the infant should be allowed to die without the experimental treatment, the view of the public as well as the opinions of bioethicists and ...
Lee, Marvin J. H.
core   +1 more source

Ethical Issues in Family Practice: Medical Futility — The debate

South African Family Practice, 2004
No abstract available.
D. Knapp van Bogaert, G.A. Ogunbanjo
doaj   +1 more source

A Bayesian adaptive marker‐stratified design for molecularly targeted agents with customized hierarchical modeling [PDF]

, 2019
It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect ...
Cao, Sha, Guo, Beibei, Han, Yan, Zang, Yong, Zhang, Chi   +4 more
core   +3 more sources

Doing more does not mean doing better: the FADOI contribution to the Slow Medicine program for a sustainable and wise healthcare system

Italian Journal of Medicine, 2015
Consistently with its own vision on the necessity to implement a sustainable and frugal medicine, in 2013 the Italian Federation of Associations of Hospital Doctors in Internal Medicine (FADOI) decided to adhere to the Slow Medicine program entitled ...
Luigi Lusiani, Roberto Frediani, Roberto Nardi, Andrea Fontanella, Mauro Campanini   +4 more
doaj   +1 more source

Predictors of consciousness improvement in patients with hypoglycemic encephalopathy

Frontiers in Endocrinology, 2022
AimsHypoglycemic encephalopathy (HE) can cause long-lasting mental changes, disability, and even death. We aimed to investigate prognostic factors for HE and to determine when the treatment of HE becomes futile.MethodsWe retrospectively evaluated the ...
Yu Eun Lee, Eun Ja Lee, Seung Eun Lee, Jinkyeong Park   +3 more
doaj   +1 more source

Integrating Phase 2 into Phase 3 based on an Intermediate Endpoint While Accounting for a Cure Proportion -- with an Application to the Design of a Clinical Trial in Acute Myeloid Leukemia

, 2019
For a trial with primary endpoint overall survival for a molecule with curative potential, statistical methods that rely on the proportional hazards assumption may underestimate the power and the time to final analysis.
Heinzmann, Dominik, Monnet, Annabelle, Rufibach, Kaspar   +2 more
core   +1 more source

Withdrawing Medically Futile Treatment [PDF]

Journal of Oncology Practice, 2009
Physicians confront clinical and ethical dilemmas when their patients wish to continue treatments they have deemed futile; they must consider ethical obligations in deciding whether treatment should be withdrawn and in transferring patients from futile treatment to supportive care.
Dianna S, Howard, Timothy M, Pawlik
openaire   +2 more sources