Results 61 to 70 of about 74,228 (295)

Integrating Phase 2 into Phase 3 based on an Intermediate Endpoint While Accounting for a Cure Proportion -- with an Application to the Design of a Clinical Trial in Acute Myeloid Leukemia

, 2019
For a trial with primary endpoint overall survival for a molecule with curative potential, statistical methods that rely on the proportional hazards assumption may underestimate the power and the time to final analysis.
Heinzmann, Dominik, Monnet, Annabelle, Rufibach, Kaspar   +2 more
core   +1 more source

Review of John McMillan, The Methods of Bioethics: An Essay in Meta-Bioethics [PDF]

, 2019
Although McMillan recognizes that moral theory has its place, he suggests that by setting bioethics up as a discipline whose predominant issues are to do with theory, not only are students insulated from the broadness of its scope and the diversity of ...
Lewis, Jonathan
core   +1 more source

Surgical Management of Recurrent Retroperitoneal Sarcomas: Experience From a High‐Volume Sarcoma Centre

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Retroperitoneal sarcoma (RPS) is a rare and complex malignancy, requiring specialized multidisciplinary care. While a significant progress has been made in managing a primary RPS, there is a limited literature on the outcomes of recurrent RPS (RecRPS).
Abdeali Saif Arif Kaderi, Tanvi M. Shah, Shraddha Patkar, Y. Aditya Sai Ram, Vinayaka S. Bairannavar, M. Myvizhi Kannan, Bharat Rekhi, Prabhat Bhargav, Kunal B. Gala, Afroj Bagwan, Mukta Ramadwar, Jifmi Jose, Nehal Khanna, Siddhartha Laskar, Mahesh Goel   +14 more
wiley   +1 more source

Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT

Efficacy and Mechanism Evaluation, 2020
Background: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction and is independently associated with adverse outcomes.
Peter J McCartney, Hany Eteiba, Annette M Maznyczka, Margaret McEntegart, John P Greenwood, Douglas F Muir, Saqib Chowdhary, Anthony H Gershlick, Clare Appleby, James M Cotton, Andrew Wragg, Nick Curzen, Keith G Oldroyd, Mitchell Lindsay, J Paul Rocchiccioli, Aadil Shaukat, Richard Good, Stuart Watkins, Keith Robertson, Christopher Malkin, Lynn Martin, Lynsey Gillespie, Thomas J Ford, Mark C Petrie, Peter W Macfarlane, R Campbell Tait, Paul Welsh, Naveed Sattar, Robin A Weir, Keith A Fox, Ian Ford, Alex McConnachie, Colin Berry   +32 more
doaj   +1 more source

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

Renouncement of renal replacement therapy: withdrawal and refusal

Brazilian Journal of Nephrology
Renouncement of renal replacement therapy (RRT) is a medical dilemma. This review covers the concept, the magnitude, the prognosis, and discusses strategies and management approaches about this subject in patients with CKD and AKI. Evidence suggests that
José Andrade Moura Neto, Ana Flávia de Souza Moura, José Hermógenes Rocco Suassuna   +2 more
doaj   +1 more source

Ventilação mecânica e obstinação terapêutica ou distanásia, a dialéctica da alta tecnologia em medicina intensiva

Revista Portuguesa de Pneumologia, 2006
Resumo: Distanásia ou qualquer um dos seus sinónimos é uma consequência do excesso terapêutico em relação ao prognóstico esperado. A obstinação terapêutica é um dos dilemas éticos mais angustiantes no quotidiano de medicina intensiva, apesar de a sua ...
Filipe Monteiro
doaj   +1 more source

The persistent vegetative state: legal and ethical issues [PDF]

, 1995
Recent advances in technology and medical expertise have enabled doctors to prolong the lives of many severely injured patients who only a few years ago would have died from their injuries. The prolongation of life by such measures has raised many legal,
Dobson, Rosemary
core  

Frequency of Medical Futility and its Costs in Deceased Neonates with a Probable Diagnosis of Inherited Metabolic Disorder in Children’s Medical Center, Iran

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Futile medical care is referred to any medical intervention or activity that bring no benefit to patients. The aim of this study was to evaluate the frequency of futile treatment and its cost in neonates with a probable diagnosis ...
Mahshid Darabi, Leila Shahbaznejad, Mansure Madani, Maliheh Kadivar   +3 more
doaj  

Conditional Estimation in Two-stage Adaptive Designs

, 2017
We consider conditional estimation in two-stage sample size adjustable designs and the following bias. More specifically, we consider a design which permits raising the sample size when interim results look rather promising, and, which keeps the ...
Broberg, Per, Miller, Frank
core   +1 more source