Results 101 to 110 of about 2,598,165 (339)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

History of the Patient’s History: Exploring Origins, Developments, and Debates of the Art of Clinical Case-Taking [PDF]

, 2014
The development of patient-centered and narrative medicine in the late modern era transformed interactions between western medical doctors and their patients. The healing process now involved treating not just the illness, but interacting in more complex
Chiao, Joanne
core   +1 more source

A survey of UK medical schools' arrangements for early patient contact [PDF]

, 2008
Background: Many U.K. medical schools have patient contact in the first two years of the undergraduate course. Aim: To compare the purposes and organization of early patient contact in UK medical schools and to relate these arrangements to the schools ...
Amanda Howe, Cade J, Carney PA, Dahle LO, Friedberg M, General Medical Council, Gray J, Haffling AC, Hampshire A, Hannay D, Howe A, Johnson AK, Kevork Hopayian, Lassen LC, Lincoln YS, Littlewood S, McLean M, Murray E, Pamies RJ, Seely Brown J, Valerie Dagley, Valkova L, Vieira JE, West M, Wilson A   +24 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Effect of Using a Checklist on Quality Improvement of History Taking from Trauma Patients

طب اورژانس ایران, 2015
Introduction: To date, no study with a proper sample size has been done to evaluate the efficiency of using pre-designed checklists in history taking of trauma patients in Iran.
Gholamreza Faridaalaee, Behzad Boushehri, Bahram Ebrahimi   +2 more
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Impact of Using a 3D Visual Metaphor Serious Game to Teach History-Taking Content to Medical Students: Longitudinal Mixed Methods Pilot Study

JMIR Serious Games, 2019
Background History taking is a key component of clinical practice; however, this skill is often poorly performed by students and doctors. Objective The study aimed to determine whether Metaphoria, a 3D serious game (SG), is superior to another electronic
Hussain Alyami, Mohammed Alawami, M. Lyndon, Mohsen M. Alyami, C. Coomarasamy, M. Henning, A. Hill, F. Sundram   +7 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Case of Ty Jackson: An Interactive Module on LGBT Health Employing Introspective Techniques and Video-Based Case Discussion [PDF]

, 2019
Introduction: The Institute of Medicine's 2011 report on lesbian, gay, bisexual, and transgender (LGBT) health and the legalization of same-sex marriage are just two of the numerous milestones that have hastened medical schools' efforts to prepare ...
Alexander, Andreia, Berenson, Marc G., Decker, Jilyan, Domogauer, Jason, Gavzy, Samuel J., Pulaski, Matthew, Soto-Greene, Maria, Sánchez, John Paul, Sánchez, Nelson   +8 more
core   +1 more source

Dysphonia risk screening protocol

Clinics, 2016
OBJECTIVE: To propose and test the applicability of a dysphonia risk screening protocol with score calculation in individuals with and without dysphonia.
Katia Nemr, Marcia Simões-Zenari, João Marcos da Trindade Duarte, Karen Elena Lobrigate, Flavia Alves Bagatini   +4 more
doaj   +1 more source