Results 121 to 130 of about 14,828,469 (259)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Medical Doctors' Independence Movement during the Japanese Colonial Period

, 2008
There are approximately 10,000 people who have been identified as men of merit for independence movement by the Ministry of Patriots and Veterans Affairs in Korea.
신규환
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Medical History Taking [PDF]

, 2020
openaire   +1 more source

Computerized history-taking as a tool to manage dyslipidemia

, 2010
David Zakim1, Christine Fritz2, Niko Braun1,3, Peter Fritz1, M Dominik Alscher1,31Institute for Digital Medicine, Stuttgart, Germany; 2University of Ulm, Ulm, Germany; 3Robert Bosch Krankenhaus, Stuttgart, GermanyBackground: Validated guidelines to ...
Christine Fritz, et al, David Zakim, Niko Braun   +3 more
core  

Student Independence Movement of Severance Union Medical College: Focusing on the Student Network and Nationwide Expansion of the March 1st Movement

, 2019
This paper examines the independence movement of students, who played an important role in the March 1st Movement, along with religious leaders. In particular, I looked into the Independence Movement developed by the students of Severance Union Medical ...
김영수
core   +1 more source

Comparison of teacher-standardized patients and peer role-play in assessing medical students’ history-taking skills

BMC Medical Education
Background Standardized patients (SPs) are widely utilized in the training of medical students’ history-taking skills. However, due to certain limitations, many institutions still rely on teachers and students to act as SPs.
Yingying Wei, Na Deng, Hongmei Zheng, Haijun Guo, Huiling Zhang, Bing Li, Daiqin Wu, Li wei, Xiaoyun Si   +8 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source