Results 141 to 150 of about 14,828,469 (259)
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Thomas C. Rowland, Jr., M.D., oral history interview, October 9, 1992
, 1992 Dr. Laurie L. Brown, M.D., conducted this oral history interview at the Medical University of South Carolina on October 9, 1992. In this interview, Dr. Thomas C.
Rowland, Thomas C., Jr.
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Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Ben Nealy Miller, M.D., oral history interview, April 7, 1995
, 1995 Dr. Charles S. Bryan, M.D., conducted this oral history interview on April 7, 1995, at the headquarters of the South Carolina Medical Association (SCMA) in Columbia, South Carolina. In this interview, Dr.
Miller, Ben Nealy
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
John D. Gilland, Jr., M.D., oral history interview, March 3, 1993
, 1993 This oral history interview, conducted by Dr. Laurie L. Brown, M.D., and Ms. Manya Greene, on March 9, 1993, in the home of Dr. John D. Gilland, M.D., in Conway, South Carolina. In this interview, Gilland discusses his personal and educational background
Gilland, John D., Jr.
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FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Edward F. Parker, M.D., oral history interview, November 11, 1992
, 1992 Dr. Laurie Brown, M.D., and Ms. Manya Greene conducted this oral history interview at the Medical University of South Carolina in Charleston on November 11, 1992. In this interview, Dr. Edward F. Parker, M.D., discusses his family, educational background,
Parker, Edward F.
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FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Hippocrates and the Nineteenth-century French medicine
, 2003 Hippocrates, the father of medicine, has been represented in many ways throughout the history of medicine. His influence on later medicine took different forms from one epoch to another Hippocrates‘ medical doctrine was quite influential until ...
여인석
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