Results 121 to 130 of about 1,824,761 (332)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

A CASE REPORT ON WILSON'S DISEASE INDUCED LIVER CIRRHOSIS [PDF]

, 2017
Wilsons disease is an inherited autosomal genetic abnormality genetic abnormality which results in impairment in cellular copper transport. Overtime this may leads to liver cirrhosis.
James, Aloysius, Reghu, Remya, Reji, Reshma, Tv, Syamaprasad, Vincent, Bini   +4 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

A study to ascertain the patients' satisfaction of the quality of hospital care in Greece compared with the patients' satisfaction in Poland [PDF]

, 2007
PURPOSE: The aim of this study is to evaluate the satisfaction of elderly patients, of the hospital care's quality, based on the literature evidence on results of a qualitative research and on a previous developed conceptual frame.
Nikolaos, Triantafyliou, Raftopoulos, Vasilios, Theodosopoulou, Eleni   +2 more
core   +1 more source

Como se Sentem Pacientes Quando Examinados por Estudantes de Medicina? Um Misto entre Ambiguidades e Satisfações Encontradas em Estudo Qualitativo

Revista Brasileira de Educação Médica
No contexto do ensino médico, pacientes são habitualmente convidados a colaborar se submetendo ao exame clínico para serem observados. Como pacientes se sentem nessa situação?
Alcir Escocia Dorigatti, Eliel Wagner Faber, Celso Garcia Junior, Egberto Ribeiro Turato   +3 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

The effective and preventive factors of taking patients\' history from the viewpoint of the students of Birjand Medical School in 2010-2011

Journal of Medical Education and Development, 2013
Introduction: Taking patients' history and doing physical examinations help physicians to diagnose correctly and treat accordingly. There are several factors which may affect the quality of taking patients' history. This study aims to assess determinants
Z. Khazaee, T. Khazaee, M. H. Namayi, E. Jananeh   +3 more
doaj  

Peer-Assisted History-Taking Groups: A Subjective Assessment of their Impact Upon Medical Students' Interview Skills

GMS Journal for Medical Education, 2017
Background and Objectives: Among the clinical skills needed by all physicians, history taking is one of the most important. The teaching model for peer-assisted history-taking groups investigated in the present study consists of small-group courses in ...
Keifenheim, Katharina Eva, Petzold, Ernst Richard, Junne, Florian, Erschens, Rebecca Sarah, Speiser, Natalie, Herrmann-Werner, Anne, Zipfel, Stephan, Teufel, Martin   +7 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A Review of the Ideal Treatment in the Emergency Department (ED) of Patients with a Suspected Hip Fracture, with a Clinical Audit of one Hospital’s Adherence to Identified Standards. [PDF]

, 2011
Background: Hip-fracture is a common orthopaedic injury presenting to the Emergency Department, which is particularly prevalent in the elderly population. The injury is usually very painful and debilitating, the recovery process is long and morbidity and
Taylor, Rebecca
core