Results 51 to 60 of about 648,180 (293)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Profile of patients attended in the Exam and Screening Sector of the Dentistry Faculty of Universidade de Passo Fundo, Rio Grande do Sul, Brazil [PDF]

open access: yesRGO: Revista Gaúcha de Odontologia, 2009
Objectives: The aim of this study is to describe the systemic diseases and dental treatment needs that most frequently affect the population of Passo Fundo, Rio Grande do Sul, Brazil and region, in patients attended at the Examination, Urgency and ...
Daiane Amarante de Mattos   +5 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Understanding interactions in interpreted triadic medical consultations in primary care [PDF]

open access: yes, 2011
Communication is one of the core clinical skills and has been taught at medical schools in many countries for some 30 years. However, the use of ad hoc and professional interpreters in medical consultations has imposed new challenges on the medical ...
Li, Shuangyu
core  

Significance of experts' overall ratings for medical student competence in relation to history-taking

open access: yesSão Paulo Medical Journal
CONTEXT AND OBJECTIVE: Overall ratings (ORs) of competence, given by expert physicians, are increasingly used in clinical skills assessments. Nevertheless, the influence of specific components of competence on ORs is incompletely understood. The aim here
Luiz Ernesto de Almeida Troncon
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Observable phenomena that reveal medical students' clinical reasoning ability during expert assessment of their history taking: a qualitative study

open access: yesBMC Medical Education, 2017
Background During their clerkships, medical students are meant to expand their clinical reasoning skills during their patient encounters. Observation of these encounters could reveal important information on the students’ clinical reasoning abilities ...
Catharina M. Haring   +4 more
doaj   +1 more source

The effect of the SNAPPS (summarize, narrow, analyze, probe, plan, and select) method versus teacher-centered education on the clinical gynecology skills of midwifery students in Iran [PDF]

open access: yesJournal of Educational Evaluation for Health Professions, 2016
This study aimed to determine the effect of the SNAPPS (summarize, narrow, analyze, probe, plan, and select) method versus teacher-centered education on the clinical skills of midwifery students in Iran.
Hamideh Barangard   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Obtaining patients’ medical history using a digital device prior to consultation in primary care: study protocol for a usability and validity study

open access: yesBMC Medical Informatics and Decision Making, 2022
Background With the help of digital tools patients’ medical histories can be collected quickly and transferred into their electronic medical records. This information can facilitate treatment planning, reduce documentation work, and improve care. However,
Klara Albrink   +5 more
doaj   +1 more source

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