Results 91 to 100 of about 13,929,601 (291)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Yixue yu zhexueThe content system of medical humanities curriculum urgently needs to be further expanded and deepened under the concepts of "comprehensive health" and "proactive health". However, the current topics of the medical humanities curriculum are still limited
Yan SHI, Zhiguang DUAN
doaj +1 more source
Integrating Human Rights into Medical Education
AMA Journal of Ethics, 2004 Educating medical students, residents, and practicing physicians about human rights can help them become more effective advocates for patients. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
Kari, Hannibal +2 more
openaire +2 more sources
Current Practices and Future Directions in Patient Safety Education and Curriculum in Medical Schools [PDF]
, 2019 In 2018, The Ministry of Health and Welfare announced its first comprehensive plan for patient safety, which included the imperative to develop a patient safety curriculum for students studying to become health professionals.
Korean Medical Education Review (의학교육논단) +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Lament for the humanities in continuing medical education [PDF]
Canadian Medical Association Journal, 2011 Every year, following my tussle with the Royal College website, I wonder when the axe will fall. Will I be disbarred first or deranged? Over four decades, continuing medical education (CME) has grown to an imperative. We cannot maintain credentials without “keeping up.” We understand why.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Transformation Pathways of Three-Dimensional Knowledge in Medical Humanities Education
Yixue yu zhexueBased on knowledge classification theory, this study explores the transformation mechanism of three dimensions of knowledge: factual knowledge, methodological knowledge, and value-based knowledge.
Lixin GONG, Yi LI, Li SHAO
doaj +1 more source