Results 71 to 80 of about 266,930 (237)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

3D printing of an optic pathway model from 7T MRI for education

3D Printing in Medicine
Background The optic pathway is a complex neural structure responsible for transmitting visual information from the retina to the brain. Traditionally, the optic pathway has been depicted using two-dimensional (2D) illustrations, which, while useful for ...
Jack A. Black, Daniel J. Blezek, Christian R. Hanson, Nic A. Crudele, Andrew M. Duit, David F. Black, Jonathan M. Morris   +6 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An Analysis of Visual Narrative in the Medical Manuscript “Lazzat Un Nisa’” [PDF]

Journal of Research on History of Medicine
Most people believe that they are adequately aware of sex and its etiquette and hence, they don’t need any education to improve their sexual knowledge. However, relevant issues that are often treatable, like sexual diseases or dissatisfaction, have made ...
Leila Rezaeian, Fahimeh Zarezadeh
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Illustrated continuing medical education [PDF]

Clinical Microbiology and Infection, 1997
Jenks, Peter, Sharma, Sanjay
openaire   +5 more sources

On the History of Creation of the Atlas of Tibetan Medicine (17th century): source aspects

Монголоведение
Introduction. The article examines the history of the creation of the set of illustrations the Atlas of Tibetan Medicine (also known as Tibetan Medical Paintings) by Desi Sangye Gyatso (1653–1705) to his Vaiḍūrya sngon po, which is a drudrel (‘bru ‘grel)
Yumzhana Zh. Zhabon
doaj   +1 more source

Cinchona amazonica Standl. (Rubiaceae) in the state of Acre, Brazil [PDF]

Boletim do Museu Paraense Emílio Goeldi. Ciências Naturais, 2006
The present research is about dendrology, geographic distribution and status of conservation of Cinchona amazonica Standl. with are plants with medical interest; they grow in the state of Acre, Brazil.
Percy Amilcar Zevallos Pollito, Mário Tomazello Filho   +1 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source