Results 81 to 90 of about 151,110 (308)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Advances in Medical Image Segmentation: A Comprehensive Review of Traditional, Deep Learning and Hybrid Approaches

Bioengineering
Medical image segmentation plays a critical role in accurate diagnosis and treatment planning, enabling precise analysis across a wide range of clinical tasks. This review begins by offering a comprehensive overview of traditional segmentation techniques,
Yan Xu, Rixiang Quan, Weiting Xu, Yi Huang, Xiaolong Chen, Fengyuan Liu   +5 more
doaj   +1 more source

BRAIN MR IMAGE SEGMENTATION BY MODIFIED ACTIVE CONTOURS AND CONTOURLET TRANSFORM

ICTACT Journal on Image and Video Processing, 2017
Multiresolution analysis is often used for image representation and processing because it can represent image at the split resolution and scale space.
P Nageswara Reddy, C P V N J Mohan Rao, Ch Satyanarayana   +2 more
doaj   +1 more source

CapsNet for medical image segmentation

Deep Learning for Medical Image Analysis, Elsevier/Academic Press (accepted)
Tran, Minh, Vo-Ho, Viet-Khoa, Quinn, Kyle, Nguyen, Hien, Luu, Khoa, Le, Ngan   +5 more
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Multi-scale Hierarchical Vision Transformer with Cascaded Attention Decoding for Medical Image Segmentation [PDF]

, 2023
Md. Mostafijur Rahman, Radu Mărculescu
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Brain tumor segmentation based on a hybrid clustering technique

Egyptian Informatics Journal, 2015
Image segmentation refers to the process of partitioning an image into mutually exclusive regions. It can be considered as the most essential and crucial process for facilitating the delineation, characterization, and visualization of regions of interest
Eman Abdel-Maksoud, Mohammed Elmogy, Rashid Al-Awadi   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

LANet for medical image segmentation

Системный анализ и прикладная информатика
The paper presents an original LANet model for improving medical image segmentation results based on MobileViT neural network. The developed and integrated Efficient Fusion Attention and Adaptive Feature Fusion blocks improve the quality of feature ...
Di Zhao, Yi Tang, D. Y. Pertsau, A. B. Gourinovitch, D. V. Kupryianava   +4 more
doaj   +1 more source