Results 81 to 90 of about 914,658 (364)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Medical Image Segmentation for Mobile Electronic Patient Charts Using Numerical Modeling of IoT

Journal of Applied Mathematics, 2014
Internet of Things (IoT) brings telemedicine a new chance. This enables the specialist to consult the patient’s condition despite the fact that they are in different places.
Seung-Hoon Chae, Daesung Moon, Deok Gyu Lee, Sung Bum Pan   +3 more
doaj   +1 more source

Improved Multistage Edge-Enhanced Medical Image Segmentation Network of U-Net [PDF]

Jisuanji gongcheng
Medical image segmentation accuracy plays a key role in clinical diagnosis and treatment. However, because of the complexity of medical images and diversity of target regions, existing medical image segmentation methods are limited to incomplete edge ...
HU Shuai, LI Hualing, HAO Dechen
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Interactive Segmentation for Medical Images Using Spatial Modeling Mamba

Information
Interactive segmentation methods utilize user-provided positive and negative clicks to guide the model in accurately segmenting target objects. Compared to fully automatic medical image segmentation, these methods can achieve higher segmentation accuracy
Yuxin Tang, Yu Li, Hua Zou, Xuedong Zhang   +3 more
doaj   +1 more source

AutoSegNet: An Automated Neural Network for Image Segmentation

IEEE Access, 2020
Neural Architecture Search (NAS) has drawn significant attention as a tool for automatically constructing deep neural networks. The generated neural networks are mainly applied for image classification, and natural language processing. However, there are
Zhimin Xu, Si Zuo, Edmund Y. Lam, Byoungho Lee, Ni Chen   +4 more
doaj   +1 more source

CapsNet for medical image segmentation

Deep Learning for Medical Image Analysis, Elsevier/Academic Press (accepted)
Tran, Minh, Vo-Ho, Viet-Khoa, Quinn, Kyle, Nguyen, Hien, Luu, Khoa, Le, Ngan   +5 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source