Results 141 to 150 of about 4,513,419 (307)

Understanding the key differences between ISO 15189:2022 and ISO 15189:2012 for an improved medical laboratory quality of service

Romanian Journal of Laboratory Medicine, 2023
Ilinca Radu, Chiriac Ionuț A., Luțescu Dan A., Ganea Ionela, Hristodorescu-Grigore Smaranda, Dănciulescu-Miulescu Rucsandra-Elena   +5 more
doaj   +1 more source

Shaping the future of medical laboratory practices in Somaliland: a review of the current standards

Discover Applied Sciences
Medical laboratory science has an acknowledged pivotal role in evidence-based practices and patient-centered care, informing clinical decision-making for precise diagnosis and treatment.
Omar Abdulkarim Saeed Alhammadi, Zhinya Kawa Othman, Ephraim Ikpongifono Udokang, Tayaba Sarfraz, Olalekan John Okesanya, Jerico Bautista Ogaya, Don Eliseo Lucero-Prisno   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cybersecurity requirement of ISO 15189 - a simplified protocol for laboratories

Romanian Journal of Laboratory Medicine, 2023
Ilinca Radu, Luțescu Dan Adrian, Chiriac Ionuț Adrian, Hristodorescu-Grigore Smaranda, Stănescu-Spînu Iulia-Ioana, Ganea Ionela, Gherlan Iuliana, Dănciulescu-Miulescu Rucsandra-Elena   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Proceedings of the third French-Ukrainian workshop on the instrumentation developments for HEP

, 2015
The reports collected in these proceedings have been presented in the third French-Ukrainian workshop on the instrumentation developments for high-energy physics held at LAL, Orsay on October 15-16.
Alessio, F., Barsuk, S. Ya., Berge, L., Bezshyyko, O. A., Boiko, R. S., Chaikovska, I., Chapellier, M., Charles, G., Chaus, A., Chehab, R., Chernyak, D. M., Coron, N., Danevich, F. A., de Marcillac, P., Delerue, N., Devoyon, L., Drillien, A. -A., Dumoulin, L., Enss, C., Fedorchuk, O., Fleischmann, A., Gastaldo, L., Giuliani, A., Gray, D., Gros, M., Herve, S., Humbert, V., Ivanov, I. M., Juillard, A., Kharchenko, D., Kharchenko, V., Khodnevych, V., Kobychev, V. V., Koskas, F., Kovalchuk, O., Levchuk, I. P., Loidl, M., Lysenko, I., Magnier, P., Makarov, E. P., Malovytsia, M., Mancuso, M., Marnieros, S., Marrache-Kikuchi, C., Maslov, V. I., Momot, I., Navick, X. -F., Nones, C., Okhrimenko, O., Olivieri, E., Onishchenko, I. N., Paul, B., Penichot, Y., Pessina, G., Plantevin, O., Poda, D. V., Prezado, Y., Pugatch, V., Redon, T., Rodrigues, M., Shchagin, A. V., Shlegel, V. N., Shul'ga, N. F., Shul'ga, S. N., Strazzer, O., Tenconi, M., Titov, M., Torres, L., Tretyak, V. I., Trofymenko, S. V., Vasiliev, Ya. V., Velazquez, M., Viraphong, O.   +72 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source