Results 131 to 140 of about 2,959,314 (265)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Comparative Evaluation of Five Multimodal Large Language Models for Medical Laboratory Image Recognition: Impact of Prompting Strategies on Diagnostic Accuracy. [PDF]

Diagnostics (Basel)
Yang HR, Lin KY, Lin PC, Tsai JJ, Chen PC.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Curriculum Implementation for the Medical Laboratory Technology Programme at an Allied Health School: A Case of Uganda Institute of Allied Health and Management Sciences. [PDF]

Adv Med Educ Pract
Ndhego R, Atwebembeire J, Oryema DE, Mumbya A, Nono D.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A STUDY OF SIMULTANEOUS ELECTRIC ACTIVITIES OF PAIN--EXCITATIOM AND PAIN--INHIBITION NEURONS IN PREOPTIC AREA AND PARAFASCICULAR NUCLEUS IN RATS

针刺研究, 1984
Li Yurong, Zhang Jiye, Sun Mingzhi Acupuncture Research Laboratory of Harbin Medical College   +2 more
doaj  

Medical laboratory science course performance and grade point average as indicators of ASCP certification success: a 10-year review from an NAACLS-accredited program. [PDF]

Lab Med
Bushra S, Abozoor R, Abu-Nada T, Al-Hamdani M, Abdallah AM, Abu-Madi M.   +5 more
europepmc   +1 more source

Hidden and Understaffed: Exploring Canadian Medical Laboratory Technologists' Pandemic Stressors and Lessons Learned. [PDF]

Healthcare (Basel), 2023
Dignos PN, Khan A, Gardiner-Davis M, Papadopoulos A, Nowrouzi-Kia B, Sivanthan M, Gohar B.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Medical laboratory data-based models: opportunities, obstacles, and solutions. [PDF]

J Transl Med
Meng J, Wu M, Shi F, Xie Y, Wang H, Guo Y.   +5 more
europepmc   +1 more source