Results 51 to 60 of about 2,823,528 (278)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Modeling geographical accessibility to medical laboratory services in Iran: methodology and its challenges

open access: yesPayesh, 2015
Objectives: Recent advances in health geography helped to understand more on the role of the geographical distribution and settings of diagnostic and therapeutic centers in the communities.
Jila Sadighi   +8 more
doaj  

Medical law: Exploring doctors' knowledge on the laws regulating clinical and medical laboratories in Nigeria.

open access: yesNigerian Journal of Medicine, 2019
BACKGROUND The Nigerian healthcare system has experienced repeated disharmony between the Medical Laboratory Scientist and the Pathologist. This may be seemingly due to lack of understanding of the Medical Laboratory Science Council of Nigeria (MLSCN ...
F Archibong   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Assessment of the Impact of Smart Refrigerators on the Preanalytical Phase to Enhance the Transport and Storage of Blood Samples in Primary Care

open access: yesNSC Nursing
Introduction: This study investigates the impact of smart refrigerators on the logistics and management of biological samples, emphasizing the critical phases of transport and storage to enhance the pre-analytical quality of blood samples.
Vidal Navarro Ana   +7 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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