Results 251 to 260 of about 2,474,653 (302)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Correction to: GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis. [PDF]

Cancer Immunol Immunother
Kłopotowska M, Baranowska I, Hajduk S, Jurga A, Leśniowska N, Łaźniewski M, Granica M, Krawczyk M, Dziewicka M, Graczyk A, Słupski J, Zagożdżon R, Plewczynski D, Winiarska M, Bajor M.   +14 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Plasma soluble CD147 levels in sepsis: the association with disease severity and the prediction for clinical outcome. [PDF]

Crit Care
Chen J, Zhang H, Sun Y, Chang Y, Tu S, Xiao Y, Yu X, Wang P, Zhang Z, Fu Y, Hu Q, Shang H, Jiang Y.   +12 more
europepmc   +1 more source

Left bundle branch vs biventricular pacing: mechanistic insights from a canine model. [PDF]

Eur Heart J
Huang H, Hu Y, Li H, Cheng S, Jiang Y, Weng S, He P, Yang J, Chen G, Liu X, Pei J, Chen L, Gu M, Ding L, Niu H, Jin H, Pan X, Vernooy K, Prinzen FW, Hua W.   +19 more
europepmc   +1 more source

Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating. [PDF]

Acta Pharmacol Sin
Dong YP, Wu Y, Zhao YL, Chen YM, Liu TY, Zhang YH, Xie JY, Zhang JF, Zhang H, Chen H, Peng Y, Zhang CL, Rau AR, Hansen KB, Xu HB, Yi F.   +15 more
europepmc   +1 more source

IL-18-armed oncolytic vaccinia virus remodels the suppressive microenvironment via macrophage and Treg modulation in lymphoma. [PDF]

Cancer Immunol Immunother
Wu H, Zhang J, Xu L, Xie Y, Pan L, Zhang X, Xia Y, Yang F, Kang X, Tong X, Wang S.   +10 more
europepmc   +1 more source