Results 111 to 120 of about 6,666,035 (292)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Medical Center status, 1951

, 1951
This glass lantern slide features a map with an aerial view of the Medical Center campus of the Medical College of South Carolina in 1951. The map is entitled, ""Medical College of South Carolina, Medical Center, Charleston, S.C.,"" and inludes numbered ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Psychosocial Care in Cancer: An overview of psychosocial programmes and national cancer plans of countries within the International Federation of Psycho-Oncology Societies

, 2012
We report data from representatives of national professional psycho-oncology societies on the integration of psychosocial care into national cancer programmes or cancer plans.
WATSON M., GRASSI, Luigi, FEDERATION OF PSYCHO ONCOLOGY SOCIETIES   +2 more
core   +1 more source

Scope of services provided to childhood cancer patients by the Brazilian Pediatric Palliative Care Network

Frontiers in Oncology
IntroductionBrazil is a developing and an Upper Middle Income, categorized by the World Bank. Therefore, it is a country that needs a special vision for children with oncological diseases who require Pediatric Palliative Care.
Esther Angélica Luiz Ferreira, Esther Angélica Luiz Ferreira, Cristina Ortiz Sobrinho Valete, Cristina Ortiz Sobrinho Valete, Silvia Maria de Macedo Barbosa, Silvia Maria de Macedo Barbosa, Graziela de Araujo Costa, Graziela de Araujo Costa, Poliana Cristina Carmona Molinari, Poliana Cristina Carmona Molinari, Ana Cristina Pugliese de Castro, Ana Cristina Pugliese de Castro, Simone Brasil de Oliveira Iglesias, Simone Brasil de Oliveira Iglesias, Maycon Rodrigo Sarracini, Maycon Rodrigo Sarracini, Rodrigo Bezerra de Menezes Reiff, Rodrigo Bezerra de Menezes Reiff, Rodrigo Bezerra de Menezes Reiff, Cristina Helena Bruno, Cristina Helena Bruno, Maria Sagrario Gómez-Cantarino, Maria Sagrario Gómez-Cantarino, Ana María Ullán   +23 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Immune inflammation indicators in anal cancer patients treated with concurrent chemoradiation: training and validation cohort with online calculator (ARC: Anal Cancer Response Classifier) [Corrigendum]

Cancer Management and Research, 2019
Casadei-Gardini A, Montagnani F, Casadei C, et al. Cancer Manag Res. 2019;11:3631–3642. The authors have advised that the affiliations are not correct in the published paper (page 3631).
Casadei-Gardini A, Montagnani F, Casadei C, Arcadipane F, Andrikou K, Aloi D, Prete AA, Zampino MG, Argentiero A, Pugliese G, Martini S, Iorio GC, Scartozzi M, Mistrangelo M, Fornaro L, Cassoni P, Marisi G, Dell'Acqua V, Ravenda PS, Lonardi S, Silvestris N, De Bari B, Ricardi U, Cascinu S, Franco P   +24 more
doaj  

The action of Palbociclib on the Cell Cycle of Head and Neck Squamous Cell Carcinoma: A Systematic Review

Brazilian Journal of Oncology
This study evaluates the action of Palbociclib in the cell cycle of HPV-negative head and neck squamous cell carcinoma. Initially approved for HER2- and HR + breast cancer.
Maria Eduarda Bertolazzi Teixeira, João Pedro Fabrini da Silva, Ana Cristina da Silva do Amaral Herrera   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source