Results 121 to 130 of about 981,832 (295)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The action of Palbociclib on the Cell Cycle of Head and Neck Squamous Cell Carcinoma: A Systematic Review

Brazilian Journal of Oncology
This study evaluates the action of Palbociclib in the cell cycle of HPV-negative head and neck squamous cell carcinoma. Initially approved for HER2- and HR + breast cancer.
Maria Eduarda Bertolazzi Teixeira, João Pedro Fabrini da Silva, Ana Cristina da Silva do Amaral Herrera   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Tislelizumab—Current Status and Future Directions: A Review Article

Indian Journal of Medical and Paediatric Oncology
Tislelizumab is a humanized IgG4 monoclonal antibody targeting programmed death-1 (PD-1), uniquely engineered to minimize Fcγ-receptor (FcγR) binding on macrophages, thereby reducing macrophage-mediated clearance of PD-1-expressing effector T cells. This
Praloy Basu
doaj   +1 more source

Uniform Reporting of Next Generation Sequencing: Indian Society of Medical and Pediatric Oncology

Molecular oncology is the cornerstone for diagnosis, treatment, prognosis, and screening of individuals who present to an oncology clinic. The integration of molecular diagnostic techniques with therapeutic management of patients has resulted in unique ...
Umut Disel, Prashant Mehta, Sadanandam, A, Vidya Veldore, Mehta, P, Pathak, N, Amol Patel, Gupta, VG, Disel, U, Chougule, A, Suryavanshi, M, Kulkarni, P, Dutt, A, Anuradha Chougule, Anguraj Sadanandam, Harsh Sheth, Neha Pathak, R. I. Anu, Sheth, H, Moushumi Suryavanshi, Tilak, TVSVGK, Tilak T. V. S. V. G. K., Padmaj Kulkarni, Patel, A, Anu, R, Vineet Govinda Gupta, Bhawna Sirohi, Amit Dutt, Veldore, V, Sirohi, B   +29 more
core   +1 more source

Precision Oncology: A Global Perspective on Implementation and Policy Development [PDF]

Precision Oncology; Policy developmentOncología de precisión; Desarrollo de políticasOncologia de precisió; Desenvolupament de polítiquesDespite the acknowledged merits of precision oncology (PO) and its increasing global implementation, its full ...
AGGARWAL, CHARU, Basel-Salmon, Lina, Dienstmann, Rodrigo, Horgan, Denis, Grover, Surbhi, Thomas, David, Tanner, Marcel   +6 more
core   +1 more source

The Future of Oncology in Psychiatric Medications

Journal of Clinical Medicine
Recent years have provided numerous reports on the mechanisms of action of psychiatric medications (antidepressants, antipsychotics, mood stabilizers, and antidementia drugs) that directly inhibit the growth of cancer cells, as well as on their indirect effects on the psyche and immune system, and their supportive effects on chemotherapeutic agents ...
openaire   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

PRECISION ONCOLOGY WITH ELECTRONIC MEDICAL RECORDS

European Medical Journal Innovations, 2018
Electronic medical record (EMR)-based precision oncology is a vision that is so far limited to a few pilot and basket studies, with the goal being the design of a proper treatment for cancer patients in real time, based on the panomics knowledge of the ...
Losiana Nayak, Rajat K. De
doaj