Results 201 to 210 of about 981,832 (295)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sexual health in cancer care: a narrative review and position statement from the Italian Association of Medical Oncology (AIOM). [PDF]

ESMO Open
Rossi A, Leone AG, Lambertini M, Sperti E, Cassani C, Vetromile A, Barni S, De Giorgi A, Preti EP, Secondino S, Silvestris N, Berardi R, Brunello A, Curigliano G, La Verde N, Latiano TP, Pietrantonio F, Tiseo M, Di Maio M, Perrone F, Cinieri S, Fabi A, Associazione Italiana Oncologia Medica (AIOM).   +22 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Correction: Biomarkers in gastroesophageal cancer 2025: an updated consensus statement by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP). [PDF]

Clin Transl Oncol
Alsina Maqueda M, Teijo Quintáns A, Cuatrecasas M, Fernández Aceñero MJ, Fernández Montes A, Gómez Martín C, Jiménez Fonseca P, Martínez Ciarpaglini C, Rivera Herrero F, Iglesias Coma M.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Addressing the Oncologist Shortage in Latin America: Insights From a Survey of Medical Oncology Fellowship Programs. [PDF]

JCO Glob Oncol
Zegarra-López M, Aranda-Gutierrez A, Muñoz Lozano JF, Villarreal-Garza C.   +3 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Workforce Trends Among Canadian Medical Oncologists and Medical Oncology Trainees over Two Decades. [PDF]

Curr Oncol
Fundytus A, Cook S, Yip SM, Loewen SK, Hao D.   +4 more
europepmc   +1 more source

Patient-reported outcomes (PROs) in clinical trials and in clinical practice: report from the XXI national conference of the Italian Association of Medical Oncology (AIOM). [PDF]

BMJ Oncol
Puccini A, Viscardi G, Ciani O, Efficace F, Piattelli A, Beretta GD, Petruzzelli D, Popoli P, De Lorenzo F, Longo F, Zibellini M, Gitto L, Brunello A, Maiello E, Servetto A, Pagliuca M, Raimondi A, Marandino L, Cinieri S, Iannelli E, Ripamonti CI, Bossi P, Numico G, Latiano T, Pinto C, Quaglini S, Locati L, Gussoni G, Mignone G, Carrera PM, Basch E, Di Maio M, Perrone F.   +32 more
europepmc   +1 more source

Medical Oncology [PDF]

, 2013
openaire   +1 more source