Results 211 to 220 of about 981,832 (295)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET). [PDF]

ESMO Open
Spada F, Gelsomino F, Rinzivillo M, Cinquini M, Fittipaldo VA, Tralongo A, Moschetti I, Albertelli M, Ambrosini V, Amoroso V, Antonuzzo L, Badalamenti G, Bajetta E, Baldari S, Barberis M, Berruti A, Bertani E, Bonomo G, Bodei L, Buzzoni R, Brizzi MP, Campana D, Capurso G, Casadei R, Castellano M, Cingarlini S, Cives M, Colao AM, Coppa J, Cremonini N, Davì MV, De Angelis CG, de Braud F, De Robertis R, Faggiano A, Falconi M, Fassan M, Ferolla P, Ferone D, Filice A, Fiore F, Funicelli L, Granata V, Giuffrida D, Grana CM, Grimaldi F, Ibrahim T, La Salvia A, Laghi A, Luppi G, Maccauro M, Marconcini R, Massironi S, Mazzaferro V, Merola E, Milione M, Modica R, Ortolani S, Papotti MG, Partelli S, Pelosi G, Pusceddu S, Ramundo V, Ravizza D, Razzore P, Reimondo G, Ricci C, Rindi G, Rizzo FM, Rossi RE, Tafuto S, Tiberio GAM, Versari A, Vigorito R, Zatelli MC, Di Maio M, Perrone F, Cinieri S, Panzuto F, Fazio N.   +79 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prevention, diagnosis and management of community acquired respiratory virus infections including COVID-19 in patients with cancer: 2025 updated evidence-based guideline of the infectious diseases working party (AGIHO) of the German society for hematology and medical oncology (DGHO). [PDF]

Ann Hematol
Giesen N, Mellinghoff SC, Khatamzas E, Korell F, Hentrich M, Einsele H, Henze L, Heußel CP, Hohmann C, Jensen BO, Monin MB, Schafhausen P, Schalk E, Spiekermann K, Voigt S, von Lilienfeld-Toal M, Teschner D, Cornely OA, Rieger C, Busch E.   +19 more
europepmc   +1 more source

Spanish Society of Medical Oncology recommendations for comprehensive assessment and care of cancer survivors' needs. [PDF]

Clin Transl Oncol
Gallego A, Beato C, Brozos E, De La Cruz S, García RV.   +4 more
europepmc   +1 more source

Medical oncology [PDF]

Cancer, 1999
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Clinical relevance and methodological approach for the assessment of drug-drug interactions in cancer patients: a position statement from the Italian Association of Medical Oncology (AIOM) and the Italian Society of Pharmacology (SIF). [PDF]

ESMO Open
Del Re M, Roncato R, Argentiero A, Berrino L, Botticelli A, Capuano A, Di Donato S, Fogli S, Marino D, Rodriquenz G, Speranza D, Perrone F, Silvestris N, Danesi R.   +13 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source