Results 91 to 100 of about 1,704,950 (362)

NEXUS/Physics: An interdisciplinary repurposing of physics for biologists [PDF]

, 2014
In response to increasing calls for the reform of the undergraduate science curriculum for life science majors and pre-medical students (Bio2010, Scientific Foundations for Future Physicians, Vision & Change), an interdisciplinary team has created NEXUS ...
AAAS, Alberts B., B. D. Geller, B. W. Dreyfus, Benedek G., C. Bauer, C. H. Crouch, C. Turpen, Crouch C. H., Cummings K., Dreyfus B., Dreyfus B. W., E. F. Redish, Freeman S., Hatano G., J. Giannini, J. Presson, J. S. Gouvea, K. L. Carleton, K. Moore, K. V. Thompson, M. Cooper, M. W. Klymkowsky, National Research Council, National Research Council, Nelson Philip, Phillips R., Phillips R., R. K. P. Zia, T. J. Cooke, V. Sawtelle, W. Losert   +31 more
core   +3 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Gated metabolic myocardial imaging, a surrogate for dual perfusion-metabolism imaging by positron emission tomography [PDF]

, 2017
Acknowledgments The authors are grateful for the help from Dr H Ali and Dr A Dawson. Funding: This study was performed using a research grant from the Aberdeen Royal Hospitals Trust's Endowment Fund, with further support from the Department of Medical ...
AlMohammad, Abdallah, Norton, Murdoch Y., Sharp, Peter F., Walton, Stephen, Welch, Andrew E.   +4 more
core   +1 more source

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Accuracy of patient dose estimation in cone beam computed tomography in breast irradiation by size‐specific dose estimates with position correction

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract This study aims to investigate the effects of the position correction of size‐specific dose estimates (SSDE) on patient dose estimation in cone beam computed tomography (CBCT). The relationship between the phantom position and absorbed dose in the right breast was studied using optically stimulated luminescence dosimeters and a simulated human
Hiroyuki Ueno, Kosuke Matsubara, Sayuri Bou, Masato Hizume   +3 more
wiley   +1 more source

Energy degrader optimization for medical beam lines [PDF]

, 2002
This paper describes the optimization of a variable energy degrader design for the Midwest Proton Radiotherapy Institute (MPRI) [1]. To optimize the energy degrader design we investigate the choice of an optimal material for the degrader, the beam emittance growth in the degrader, and the matching of the degraded beam with the acceptance of a medical ...
arxiv   +1 more source

Medical physics aspects of cancer care in the Asia Pacific region [PDF]

, 2008
Medical physics plays an essential role in modern medicine. This is particularly evident in cancer care where medical physicists are involved in radiotherapy treatment planning and quality assurance as well as in imaging and radiation protection.
A Krisanachinda, A Kumara, Almond, CC Lee, D Soejoko, Eudaldo, Fraass, Holmberg, J Dai, JY Song, K Inamura, KH Ng, Kutcher, KY Cheung, L Bold, L Rodriguez, Millar, P Ravindran, R Srivastava, Round, Schlegel, T Kron, Thomadsen, Thomas, TJ Wong, XC Nguyen, Yin, Zubizarreta   +27 more
core   +2 more sources

Decoding multicellular interaction networks–a new horizon in tumor microenvironment research

Molecular Oncology, EarlyView.
Cells in the tumor microenvironment influence tumor establishment and progression through an elaborate array of cellular interactions. Integrating transcriptomic, spatial, and intercellular crosstalk data at single‐cell resolution unveil complex, functionally distinct multicellular circuits.
Roi Balaban, Merav Cohen
wiley   +1 more source

Evaluation of patient doses for routine digital radiography procedures toward establishing an institutional diagnostic reference levels: A case study in Sri Lanka

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract The present study was conducted as part of a comprehensive work to establish National Diagnostic Reference Levels (NDRLs) in Sri Lanka for the first time. DRLs can be used as an effective optimization tool for identifying unusually high or low patient doses during X‐ray examinations.
Sachith Welarathna, Sivakumar Velautham, Mihira Wanninayake, Sivananthan Sarasanandarajah   +3 more
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source