Results 71 to 80 of about 805,649 (283)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Emergent properties hidden in plane view: Strong electronic correlations at oxide interfaces

open access: yes, 2014
Finding new collective electronic states in materials is one of the fundamental goals of condensed matter physics. Atomic-scale superlattices formed from transition metal oxides are a particularly appealing hunting ground for new physics.
Chakhalian, Jak   +4 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Virtual Mentoring for Medical Physicists: Results of a Global Online Survey

open access: yesJournal of Medical Physics
Purpose: Medical physics professional development is limited in parts of the globe and can be aided by virtual mentoring. A global online perception survey was conducted to elucidate the characteristics of the preferred virtual mentoring program. Methods:
Jacob Van Dyk   +3 more
doaj   +1 more source

Operational Experience and First Results with a Highly Granular Tungsten Analog Hadron Calorimeter

open access: yes, 2011
Precision physics at future multi-TeV lepton colliders such as CLIC requires excellent jet energy resolution. The detectors need deep calorimeter systems to limit the energy leakage also for very highly energetic particles and jets.
Simon, Frank
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Large size LYSO crystals for future high energy physics experiments [PDF]

open access: yes, 2005
Because of their high stopping power and fast bright scintillation, cerium doped silicate based heavy crystal scintillators, such as GSO, LSO, and LYSO, have been developed for medical instruments.
Chen, Jianming   +2 more
core  

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Time of flight for photon in human skin

open access: yesJournal of Biomedical Photonics & Engineering, 2016
The time of flight for photons in human skin was measured using picosecond diode laser. Two different wavelength lasers were used - 405 nm and 510 nm. A difference for time of flight in normal skin and in nevus was observed as well as a difference for ...
Antra Dzerve   +3 more
doaj   +1 more source

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