Results 51 to 60 of about 790,793 (333)

Solving the Solar Neutrino Problem 2 km Underground -- the Sudbury Neutrino Observatory

, 2003
The Sudbury Neutrino Observatory (SNO) is capable of measuring simultaneously the flux of electron-type neutrinos and the total flux of all active flavours of neutrinos originating from the Sun. A model-independent test of neutrino flavour transformation
Poon, A. W. P.
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Electrical Characterization of SiPM as a Function of Test Frequency and Temperature

, 2012
Silicon Photomultipliers (SiPM) represent a promising alternative to classical photomultipliers, for instance, for the detection of photons in high energy physics and medical physics.
Boschini, M. J., Consolandi, C., Fallica, P. G., Gervasi, M., Grandi, D., Mazzillo, M., Pensotti, S., Rancoita, P. G., Sanfilippo, D., Tacconi, M., Valvo, G.   +10 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Geant4 based engineering tool for Fresnel lenses

, 2007
Geant4 is a Monte Carlo radiation transport toolkit that is becoming a tool of generalized application in areas such as high-energy physics, nuclear physics, astroparticle physics, or medical physics.
Costa, João, Pimenta, Mário, Tomé, Bernardo   +2 more
core   +1 more source

Commissioning of the J-PET detector for studies of decays of positronium atoms [PDF]

, 2017
The Jagiellonian Positron Emission Tomograph (J-PET) is a detector for medical imaging of the whole human body as well as for physics studies involving detection of electron-positron annihilation into photons.
Białas, P., Curceanu, C., Czerwiński, E., Dulski, K., Gajos, A., Gorgol, M., Głowacz, B., Hiesmayr, B. C., Jasińska, B., Kisielewska, D., Korcyl, G., Kowalski, P., Kozik, T., Krawczyk, N., Krzemień, W., Kubicz, E., Mohammed, M., Moskal, P., Niedźwiecki, Sz., Pawlik-Niedźwiecka, M., Pałka, M., Raczyński, L., Rudy, Z., Sharma, N. G., Sharma, S., Shopa, R. Y., Silarski, M., Skurzok, M., Wieczorek, A., Wiślicki, W., Zgardzińska, B., Zieliński, M.   +31 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Companding technique for high dynamic range measurements using gafchromic films

, 2011
We propose a methodology to perform dose measurements using gafchromic films which can span several decades of dose levels. The technique is based on a rescaling approach using different films irradiated at different dose levels.
Battum, Childress, Coleman, Defraene, Dolby, Durante, Frank Van den Heuvel, Georg, Gilles Defraene, Micke, Smith, Williamson, Wouter Crijns, Zhu   +13 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source