Results 41 to 50 of about 58,397 (260)

Data Resource Profile: The Rochester Epidemiology Project (REP) medical records-linkage system [PDF]

International Journal of Epidemiology, 2012
The Rochester Epidemiology Project (REP) medical records-linkage system was established in 1966 to capture health care information for the entire population of Olmsted County, MN, USA. The REP includes a dynamic cohort of 502 820 unique individuals who resided in Olmsted County at some point between 1966 and 2010, and received health care for any ...
Jennifer L, St Sauver, Brandon R, Grossardt, Barbara P, Yawn, L Joseph, Melton, Joshua J, Pankratz, Scott M, Brue, Walter A, Rocca   +6 more
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Validação de Instrumento de Registro do Atendimento Clínico Centrado na Pessoa

Revista Brasileira de Educação Médica
Diante do desafio de formar médicos para o século XXI, em que se pretende uma abordagem integral da pessoa, incluindo seus sentimentos e o contexto que a cerca, este trabalho teve como objetivo validar, para a realidade de uma cidade brasileira, um ...
Bruna Carvalho Costa França, Taciana de Figueiredo-Soares, Antonio Carlos Toledo Júnior, Nathan Mendes Souza, Rosa Malena Delbone de Faria   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Falling short: examination of the validity of methods used to identify paediatric hospital falls in NSW, Australia

Public Health Research & Practice, 2020
Objective: Hospital falls are a major cause of costly harm. This descriptive epidemiological study reports the results of a data linkage and medical record review to examine the relative utility of these methods for identifying paediatric in-hospital ...
Daniela Feuerlicht , Maria Agaliotis , Reece Hinchcliff   +2 more
doaj   +1 more source

The Family Nurse Partnership to reduce maltreatment and improve child health and development in young children: the BB:2–6 routine data-linkage follow-up to earlier RCT

Public Health Research, 2021
Background: The short-term effectiveness (to 24 months post partum) of a preventative home-visiting intervention, the Family Nurse Partnership, was previously assessed in the Building Blocks trial (BB:0–2).
Michael Robling, Fiona Lugg-Widger, Rebecca Cannings-John, Julia Sanders, Lianna Angel, Sue Channon, Deborah Fitzsimmons, Kerenza Hood, Joyce Kenkre, Gwenllian Moody, Eleri Owen-Jones, Rhys Pockett, Jeremy Segrott, Thomas Slater   +13 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Creating a Powerful Platform to Explore Health in a Correctional Population: A Record Linkage Study.

PLoS ONE, 2016
We used record linkage to create a data repository of health information of persons who were federally incarcerated in Ontario and Canada. We obtained records from 56,867 adults who were federally incarcerated between January 1, 1998 and December 31 ...
Kathryn E McIsaac, Shanna Farrell MacDonald, Nelson Chong, Andrea Moser, Rahim Moineddin, Angela Colantonio, Avery Nathens, Flora I Matheson   +7 more
doaj   +1 more source

First-generation migrants’ use of psychotropic medication in Northern Ireland: a record linkage study [PDF]

International Journal of Mental Health Systems, 2019
Abstract Purpose There is a recent and growing migrant population in Northern Ireland. However, rigorous research is absent regarding access to mental health care by different migrant groups. In order to address this knowledge gap, this study aimed to identify the relative use of psychotropic medication between the ...
Tania Bosqui, Dermot O’Reilly, Ari Väänänen, Kishan Patel, Michael Donnelly, David Wright, Ciara Close, Anne Kouvonen   +7 more
openaire   +6 more sources