Results 51 to 60 of about 8,285,529 (212)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Social Accountability of Medical Schools: Concept and Implementation [PDF]

, 2019
Medical schools have been working to produce competent doctors and improve the quality of care by introducing and implementing new curricula and innovative teaching and learning methods.
Korean Medical Education Review (의학교육논단)
core   +1 more source

Validação de Instrumento de Registro do Atendimento Clínico Centrado na Pessoa

Revista Brasileira de Educação Médica
Diante do desafio de formar médicos para o século XXI, em que se pretende uma abordagem integral da pessoa, incluindo seus sentimentos e o contexto que a cerca, este trabalho teve como objetivo validar, para a realidade de uma cidade brasileira, um ...
Bruna Carvalho Costa França, Taciana de Figueiredo-Soares, Antonio Carlos Toledo Júnior, Nathan Mendes Souza, Rosa Malena Delbone de Faria   +4 more
doaj   +1 more source

Creating a Powerful Platform to Explore Health in a Correctional Population: A Record Linkage Study.

PLoS ONE, 2016
We used record linkage to create a data repository of health information of persons who were federally incarcerated in Ontario and Canada. We obtained records from 56,867 adults who were federally incarcerated between January 1, 1998 and December 31 ...
Kathryn E McIsaac, Shanna Farrell MacDonald, Nelson Chong, Andrea Moser, Rahim Moineddin, Angela Colantonio, Avery Nathens, Flora I Matheson   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A process to deduplicate individuals for regional chronic disease prevalence estimates using a distributed data network of electronic health records

Learning Health Systems, 2022
Introduction Learning health systems can help estimate chronic disease prevalence through distributed data networks (DDNs). Concerns remain about bias introduced to DDN prevalence estimates when individuals seeking care across systems are counted ...
Kenneth A. Scott, Sara Deakyne Davies, Rachel Zucker, Toan Ong, Emily McCormick Kraus, Michael G Kahn, Jessica Bondy, Matt F. Daley, Kate Horle, Emily Bacon, Lisa Schilling, Tessa Crume, Romana Hasnain‐Wynia, Seth Foldy, Gregory Budney, Arthur J. Davidson   +15 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Effect of inpatient and outpatient care on treatment outcome in tuberculosis: a cohort study

Revista Panamericana de Salud Pública, 2018
Objective. To identify individual- and health services–related factors associated with deaths in subjects diagnosed with tuberculosis (TB). Methods. A nonconcurrent cohort study with passive follow-up was conducted using a probabilistic linkage method to
Marli S. Rocha, Gisele P. Oliveira, Valéria Saraceni, Fernanda P. Aguiar, Claudia M. Coeli, Rejane S. Pinheiro   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source