Results 71 to 80 of about 73,014,182 (263)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

open access: yesAdvanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English   +9 more
wiley   +1 more source

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

open access: yesAdvanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato   +9 more
wiley   +1 more source

A guide to ethical conduct and behaviour - 5th ed. / Medical Council [PDF]

open access: yes, 1998
Medical Council ...
Medical Council, The
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TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

open access: yesAdvanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne   +15 more
wiley   +1 more source

Medical Research Council of Ireland annual report for the year ended 31st March 1985

open access: yes, 1985
The year under review started with the Council being invited to meet the Minister for Health, Mr. Barry Desmond, in early January. He proposed the merger of the Medico Social Research Board and the Medical Research Council with some elements of the ...
Medical Research Council of Ireland
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Medical Research Council of Ireland annual report for the year ended 31st December 1977 [PDF]

open access: yes, 1977
The Council is fully aware of a considerable medical research potential in our community and of the frustrations aroused by its ineffective expression. As a granting agency it is limited by its slender appropriation in several ways. Most significantly
Medical Research Council of Ireland
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WISDOM: history and early demise - was it inevitable?

open access: yes, 2002
In 1989, the UK Medical Research Council (MRC) agreed that, if feasible, a randomized controlled trial to assess the long-term risks and benefits of hormone replacement therapy (HRT) was a priority.
Darbyshire, J, Meade, T, Vickers, M
core   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken   +8 more
wiley   +1 more source

Medical Research Council of Ireland annual report for the year ended 31st December 1986

open access: yes, 1986
By January, 1986 one year had passed since the meeting between the Minister for Health. Mr. Barry Desmond, and the Council in the Custom House. In the year under review matters moved more or less inexorably towards a merger of the functions of the ...
Medical Research Council of Ireland
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Medical Council mid term report 1984-1986 [PDF]

open access: yes, 1987
Although the concept of control of its own activities by the profession itself goes back to 1858 it is not yet sufficiently.appreciated that the foundation of the Medical Council marked a sharp break with the past. The Medical Registration Council had.
Medical Council
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