Results 61 to 70 of about 6,324,799 (359)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Student satisfaction in clinical area subjects during the COVID-19 pandemic in a medical school

Frontiers in Education
IntroductionCoronavirus SARS-CoV-2 had an impact on health and education, among other subjects. It caused changes in teaching medicine. The objective of the study was to determine student satisfaction in the subjects of the clinical area in a medical ...
Anibal Diaz-Lazo, Aldo Alvarez-Risco, Carlo Córdova Rosales, Sandra Cori Rosales, Mely Ruiz-Aquino, Mely Ruiz-Aquino, Shyla Del-Aguila-Arcentales, Neal M. Davies, Christian R. Mejia, Jaime A. Yáñez   +9 more
doaj   +1 more source

Communication training is inadequate: the role of deception, non-verbal communication, and cultural proficiency

Medical Education Online, 2020
In this commentary, we argue that the limited experiential exposure of medical students to different cultures makes the instruction devoted to communication skills inadequate.
Aaron D. Baugh, Allison A. Vanderbilt, Reginald F. Baugh   +2 more
doaj   +1 more source

Pipeline Programs [PDF]

, 2017
Pipeline programs are designed to prepare and inspire students to pursue careers in medicine and medical research. SKMC is committed to providing experiences and education to middle school, high school, college, and graduate students from groups ...

core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Dermatology – a compulsory part of the UK medical school curriculum? [PDF]

Medical Education Online, 2015
Dermatological conditions form a significant number of consultations seen by general practitioners on a daily basis. There is a lack of training and formal assessment of dermatology during medical school and we propose that there should be a mandatory ...
Hemal Shah, Lucia Pozo-Garcia, Marinos Koulouroudias   +2 more
doaj   +1 more source

Prevalence of the common coding variant rs2241880 of the ATG16L1 gene in Maltese Crohn’s disease patients [PDF]

, 2012
In Crohn's disease the ATG16L1 (rs2241880) polymorphism affects Paneth cells and impairs autophagosome formation specifically after activation of nucleotide-binding oligomerisation domain 2 (NOD2).
Azzopardi, Neville, Eighth Malta Medical School Conference, Ellul, Pierre, Grech, Godfrey, LaFerla, Godfrey, Malta Medical School Conference 2012, Saliba, Christian   +6 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Preference Signals and Interview Invitations: Insight Into Recent Updates to the Oto‐HNS Residency Application Process

OTO Open
Objective While students in the 2023 Otolaryngology–Head and Neck Surgery (Oto‐HNS) residency match were allowed 7 preference signals, this number increased to 25 for the 2024 match with the goal of reducing the overall application volume.
Radhika Duggal, Kyra Osborne, Alan Kominsky, William S. Tierney   +3 more
doaj   +1 more source