Results 91 to 100 of about 3,408,002 (265)

The role of brain magnetic resonance spectroscopy in assessment of patients with minimal hepatic encephalopathy

Journal of Medicine in Scientific Research
Background: It appears that mild and hidden Hepatic Encephalopathy (HE) is present in up to 50% of patients with chronic liver disease. Tools that can predict when HE episodes would occur may enable early detection and clinically relevant preventative ...
Zeinab Moustafa Moustafa Metwalli, Mohammed Emadeldeen, Waseem Mohamad Mahmoud El Gendy, Rania Mostafa Mahmoud, Heba Abdelaziz   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Predictors of Mortality among Under-five Children Hospitalized with Severe Community-acquired Pneumonia. A Retrospective Observational Study

Journal of Medicine in Scientific Research
Background Severe community-acquired pneumonia (SCAP) remains a critical public health issue and a leading cause of childhood mortality and morbidity, especially in developing countries.
Marwa Taha
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Prevalence of Diabetic-nephropathy in Children and Adolescents with Type-one- Diabetes Mellitus: A Recent Perspective

Journal of Medicine in Scientific Research
Background Among the most important microvascular complications in Type-one-Diabetes Mellitus (T-1-DM) in adolescents and children, Diabetic-nephropathy (DN) stands high.
Randa Mohamed Darwish, Ayat Ibrahim Ghanem, Jehan Ibrahim Altohamy, Dina Mahmoud Khalifa   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

What is the association between iron deficiency anemia and the frequency or severity of febrile seizures in children under the age of 5?

Journal of Medicine in Scientific Research
Background and Aim Febrile seizures (FS) are a common type of convulsion in young children and are frequently associated with fever in the absence of a central nervous system infection.
Rehab Fawzy Abdel Mohsen Soliman, Samar Mahmoud Ahmed, Yasmen Ahmed Said, Shaimaa Mohamed Hassan, Dalia Hassanin Hussin, Dina Gaber Soliman, Zeinab Abdalla Ali, Eman Farouk Osman   +7 more
doaj   +1 more source

The Medical Sciences [PDF]

Science, 1922
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluation of the Serum Levels of IL6 and Magnesium in Chronic Kidney Disease Patients (CKD), and CKD Patients with Different Comorbidities

Journal of Medicine in Scientific Research
Background Chronic kidney disease (CKD) is a global health concern that causes a substantial increase in morbidity and mortality rates among adults. CKD is accompanied with several complications including cardiovascular disease (CVD) and death.
Naglaa F. Al-Mihy, Nesreen M. Zakaria, Dina A. Ibrahim   +2 more
doaj   +1 more source