Results 71 to 80 of about 3,408,002 (265)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Prospective Validation and Comparison of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) and Site Other Than Lower Limb, Immunosuppression, Age, Renal Impairment, and Inflammatory Markers (SIARI) Scoring Systems for Necrotizing Fasciitis IN critically Ill Patients.

Journal of Medicine in Scientific Research
Background Necrotizing soft tissue infections (NSTIs) are rapidly progressive infections that are dangerous to life, with high morbidity and mortality.
Talal Ibrahim mostafa Hagag, Shimaa Mohamed kalama   +1 more
doaj   +1 more source

THE INSTITUTE OF MEDICAL SCIENCES AND THE MEDICAL CURRICULUM. [PDF]

The Lancet, 1906
n ...
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Perioperative Dexmedetomidine Improve Outcomes after CABG Surgery.

Journal of Medicine in Scientific Research
Background Dexmedetomidine, is used in cardiac surgeries for its sedation, anxiolysis, and analgesic properties, with minimal respiratory depression.
Reham Salah, Ismail Rafik Barada, Mazen Isam Eldein Ali   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Frequency Of Autoimmune Primary Adrenal Insufficiency In Children And Adolescents With Type 1 Diabetes Mellitus

Journal of Medicine in Scientific Research
Background Type 1 diabetes mellitus (T1DM) is a chronic endocrine disorder of autoimmune origin with a predisposition to the development of further autoimmune diseases, including autoimmune adrenal insufficiency (Addison’s disease). Although uncommon and
Randa Mohamed Darwish, Ayat Ibrahim Ghanem, Lamis Safwat Mubarak   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Outcomes of Endoscopic Third Ventriculostomy (ETV) in Hydrocephalus Secondary to Aqueductal Stenosis after Age of Anterior Fontanel Closure

Journal of Medicine in Scientific Research
Background: Non-communicated hydrocephalus secondary to aqueductal stenosis is common, for which endoscopic third ventriculostomy (ETV) has emerged as an effective surgical management.
Mohammad Abdulsalam Soliman, Eslam Abozeid Kandil, Mahmoud Moustafa Taha, Hassan Ahmed Abaza   +3 more
doaj   +1 more source

PROGRESS OF MEDICAL SCIENCE, MEDICINE [PDF]

The American Journal of the Medical Sciences, 1902
WILLIAM OSLER, W. S. THAYER
openaire   +1 more source