Results 121 to 130 of about 5,849,921 (287)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Just shamans and healers or indigenous medical systems? A critical discourse analysis of the categories of shamans and healers as constructed by social science texts [PDF]

open access: yes
"Just as even a single sentence has traditionally been taken to imply a whole language so a single discourse implies a whole society." Language and Power, N. Fairclough.
Moreno-Leguizamon, Carlos
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Laboratories Medical Bioinformatics set up at Medical Sciences University [PDF]

open access: yes, 2017
دست‌یابی به تکنولوژی‌های جدید در علوم زیستی و پزشکی، همچون توالی‌یابی نسل بعد، زمینه پیشرفت سریع‌تر از پیش مطالعات را فراهم نموده است. از این رو، حجم بسیار عظیمی از اطلاعات اولیه فراهم می‌گردد و همچنان نیز رو به افزایش است. طراحی
Ghasemi, Soraya., Tahmasebian, Shahram.
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Homoseksualiteit in het spanningsveld tussen literatuur en wetenschap

open access: yesNeerlandica Wratislaviensia
In her book Anders dan de anderen (2024), Mary Kemperink investigates the evolution of the concept of homosexuality through a detailed analysis of both literary and medical texts.
Bożena Czarnecka
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Medical-ethical guidelines: Coercive measures in medicine

open access: yesSwiss Medical Weekly, 2015
Swiss Academy of Medical Sciences
doaj   +1 more source

Studying the Status of Academic Self-efficacy and its Relationship with Research Self-efficacy in Students of Jahrom University of Medical Sciences, 2024 [PDF]

open access: yesJournal of Medical Education and Development
Introduction: Given the unclear relationship between academic and research self-efficacy and, the present study investigated the association of academic self-efficacy and research self-efficacy in students of Jahrom University of Medical Sciences in 2024.
Fatemeh Rezaei   +5 more
doaj  

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