Results 31 to 40 of about 11,926 (263)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A Blockchain-Based Secure Inter-Hospital EMR Sharing System

Applied Sciences, 2020
In recent years, blockchain-related technologies and applications have gradually emerged. Blockchain technology is essentially a decentralized database maintained by the collective, and it is now widely applied in various fields.
Chin-Ling Chen, Yong-Yuan Deng, Wei Weng, Hongyu Sun, Ming Zhou   +4 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Privacy of human reproductive health information: digital challenges and regulatory issues

Репродуктивная эндокринология
Background. The digitalization of healthcare, the rapid expansion of mobile applications and integrated mHealth platforms, as well as the increasing use of artificial intelligence, are reshaping the ways reproductive data are collected, processed, and ...
A.I. Subbot, K.O. Kalachenkova, V.V. Berch, A.V. Basalaeva, B.P. Ratushna, V.I. Prodan   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Lightweight Mutual Authentication and Key Agreement Scheme for Medical Internet of Things

IEEE Access, 2019
Wireless body area networks play an indispensable role in the medical Internet of Things. It is a network of several wearables or implantable devices that use wireless technologies to communicate.
Zisang Xu, Cheng Xu, Wei Liang, Jianbo Xu, Haixian Chen   +4 more
doaj   +1 more source

An Efficient Lightweight Provably Secure Authentication Protocol for Patient Monitoring Using Wireless Medical Sensor Networks

IEEE Access, 2023
The refurbishing of conventional medical network with the wireless medical sensor network has not only amplified the efficiency of the network but concurrently posed different security threats.
Garima Thakur, Sunil Prajapat, Pankaj Kumar, Ashok Kumar Das, Sachin Shetty   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

A Novel Medical Image Signcryption Scheme Using TLTS and Henon Chaotic Map

IEEE Access, 2020
In tele-medicine, images based on patient diagnostic tests and reports are usually required to broadcast securely so that recipient can receive them without any error.
Tahir Sajjad Ali, Rashid Ali
doaj   +1 more source