Results 71 to 80 of about 7,206,319 (305)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Establishing the pivotal role of infectious diseases and clinical microbiology professional societies: A global survey

Journal of Global Antimicrobial Resistance
Objective: The role of medical professional societies extends beyond the regulation of medical practice. They also facilitate lifelong learning among healthcare professionals.
Heiman Wertheim, Celine Pulcini, Fee Johnstone, Jeroen Schouten, Souha S. Kanj, Robert Skov   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The International Society of Glomerular Disease: Building the Future of Glomerular Medicine

Glomerular Diseases, 2023
Laurel J. Damashek, Sharon G. Adler, Joshua M. Tarnoff, Tobias B. Huber   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Recommendations of the EANS Global and Humanitarian Neurosurgery Committee for sustainable neurosurgical partnerships in low-resource settings

Brain and Spine
Background: Despite growing interest in global neurosurgery, equitable access to neurosurgical care in low- and middle income countries (LMICs) remains limited.
Nicolò Marchesini, Vicki M. Butenschoen, Andreas K. Demetriades, Said Idrissa Ahmada, Kostantinos Gousias, Fazlul Hoque, Thomas Kapapa, Patrick D. Kamalo, Pablo González-López, Jesus Lafuente, Nigel Mendoza, Rupavathana Mahesperan, Wouter A. Moojen, Vincenzo Paternò, Ondra Petr, Wilco C. Peul, Lukas Rasulic, Nicephorus Boniface Rutabasibwa, Jamil Rzaev, Ellianne J. dos Santos Rubio, Abenezer Tirsit Aklilu, Jake Timothy, Massimiliano Visocchi, Oleksandr Voznyak, Enoch O. Uche, Magnus Tisell   +25 more
doaj   +1 more source

A searchable database of medical education objectives – creating a comparable gold standard

BMC Medical Education, 2018
Background Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common “gold standard” resource used building curricula are medical objectives suggested by national societies.
Sam Brooks, Namita Biala, Sage Arbor
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source