Results 71 to 80 of about 614,996 (241)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Brain and SpineBackground: Despite growing interest in global neurosurgery, equitable access to neurosurgical care in low- and middle income countries (LMICs) remains limited.
Nicolò Marchesini +25 more
doaj +1 more source
A searchable database of medical education objectives – creating a comparable gold standard
BMC Medical Education, 2018 Background Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common “gold standard” resource used building curricula are medical objectives suggested by national societies.
Sam Brooks, Namita Biala, Sage Arbor
doaj +1 more source
History of Key Events in Women’s Health Care
, 2016 In 1973, ninety-three percent of all American doctors were men (Ehrenreich and English). Gender based inequity permeates all spheres of women’s health care from employment to access to treatment to biologically-based myths of male superiority, yet women ...
Chambliss, Zoё M.
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The Foraker Group Report on the Alaska Nonprofit Economy: 2010 Update [PDF]
, 2010 A report on the economic importance of Alaska’s nonprofit sector conducted by the Institute of Social and Economic Research University of Alaska AnchorageThe Foraker GroupWhat is the Nonprofit Sector?
Goldsmith, Oliver Scott +1 more
core
The process of setting micronutrient recommendations: a cross-European comparison of nutrition-related scientific advisory bodies [PDF]
, 2010 Copyright @ The Authors 2010Objective: To examine the workings of the nutrition-related scientific advisory bodies in Europe, paying particular attention to the internal and external contexts within which they operate.
Anne-Mette Sonne +28 more
core +5 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
THE ROLE OF PEDIATRICIANS IN CARING FOR THE WELL-BEING OF CHILDREN LIVING IN NEW TYPES OF FAMILIES
Педиатрическая фармакология, 2017 .
Pietro Ferrara +5 more
doaj +2 more sources