Results 101 to 110 of about 658,548 (314)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

52nd Annual Medical Student Research Forum

, 2014
The 52nd Annual Medical Student Research Forum at UT Southwestern Medical Center (Tuesday, February 4, 2014, 3-6 p.m., D1.502)This 100-page booklet is the proceedings of the 52nd Annual Medical Student Research Forum and includes a list of oral ...

core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The medical student [PDF]

, 1904
The Medical Student was published from 1888-1921 by the students of Boston University School of ...
Loring, Benjamin T., Woodbury, Benj. C., Jackowitz, G.J., Guy, W. Bryant   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

53rd Annual Medical Student Research Forum

, 2015
The 53rd Annual Medical Student Research Forum at UT Southwestern Medical Center (Monday, January 26, 2015, 2-5 p.m., D1.602)The publicly-accessible version of this booklet has page 11 removed at the request of the mentor. The full version of the booklet

core  

The medical student [PDF]

, 1893
The Medical Student was published from 1888-1921 by the students of Boston University School of ...
Carleton, Francis B., Curtis, Marvin A., Worster, Willard Parker, Clapp, H. C., Amsden, Henry H., Greene, H. W., Woodvine, D. G., Coffman, G. W., Pratt, Mara L., Boothby, A., Wentworth, Caroline V., Crocker, H. C., Farwell, Charles L., Kennedy, James S., Currier, May C., Owen, Mary A., Roberts, Percival W., Francis, Adeline E., Smith, Laura M.   +18 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The medical student [PDF]

, 1900
The Medical Student was published from 1888-1921 by the students of Boston University School of ...
MacDougall, D., Sutherland, John P., Rise, George B., Thomas, Charles H., Allen, Paul, Bothfeld, James F., Wiggin, Ralph Cleaves, Wells, David W., Clapp, J. Wilkinson, Gardner, David Moulton, Hobson, Sarah M., Williams, Dudley A., Butler, D.P., Percy, Fred B., Burpee, Carroll C., Richardson, Frank C., Cooke, H. C., Martin, G. Forrest, Sproull, John   +18 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source