Results 61 to 70 of about 38,633 (297)

Integrating semantic information into multiple kernels for protein-protein interaction extraction from biomedical literatures.

PLoS ONE, 2014
Protein-Protein Interaction (PPI) extraction is an important task in the biomedical information extraction. Presently, many machine learning methods for PPI extraction have achieved promising results.
Lishuang Li, Panpan Zhang, Tianfu Zheng, Hongying Zhang, Zhenchao Jiang, Degen Huang   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

How to use the medical subject headings (Me SH ) [PDF]

International Journal of Clinical Practice, 2016
A thorough understanding of the National Library of Medicine's Medical Subject Headings can increase the efficiency and precision of one's literature searching skills using the Medline database.To describe how to use the Medical Subject Headings to conduct a search for literature, and how to write up a description of the search strategy.The author ...
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Squamous cell carcinoma arising from chronic lymphedema: case report and review of the literature

São Paulo Medical Journal
CONTEXT: Squamous cell carcinoma arising from chronic lymphedema has only been reported in the literature 11 times (12 cases). Some aspects of its pathogenesis remain unclear and, for the first time, attention has been drawn to epidemiological data. CASE
Carlos Augusto Gomes, Camila Beatriz Silva Magalhães, Cleber Soares Junior, Rodrigo de Oliveira Peixoto   +3 more
doaj   +1 more source

Use of AbobotulinumtoxinA in Adults with Cervical Dystonia: A Systematic Literature Review

Toxins, 2020
Cervical dystonia (CD) is a neurological movement disorder characterized by sustained involuntary muscle contractions. First-line therapy for CD is intramuscular injections of botulinum neurotoxin (e.g., abobotulinumtoxinA) into the affected muscles. The
Alfonso Fasano, Vijayashankar Paramanandam, Mandar Jog   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Probiota İlaçlarinda Sahtecilik

, 2022
Aim: Counterfeit drugs are a threat to human health worldwide. It can be seen that insufficient research has been conducted on the subject of counterfeit drugs related to potentially addictive drugs seized by the authorities. The aim of this study was to
Celbiş, Osman, Mucahit ORUÇ, Altın, İsmail, İsmail ALTIN, Duman, Yücel, Yücel DUMAN, Osman CELBİŞ, Oruç, Mücahit   +7 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Role of Multidetector Computed Tomography in Clinically Suspected Cases of Small- and Large-bowel Obstruction

Journal of the Scientific Society
This review was conducted to assess the function of multidetector computed tomography (MDCT) in cases of acute small intestinal obstruction with clinical suspicion. We looked through the electronic MEDLINE, EMBASE, Cochrane, and PubMed databases.
Iram Saifi, Shivali Kashikar, Pratapsingh H. Parihar, Gaurav Vedprakash Mishra, Mayur Wanjari   +4 more
doaj   +1 more source