Results 71 to 80 of about 8,199,790 (258)

Role of Multidetector Computed Tomography in Clinically Suspected Cases of Small- and Large-bowel Obstruction

Journal of the Scientific Society
This review was conducted to assess the function of multidetector computed tomography (MDCT) in cases of acute small intestinal obstruction with clinical suspicion. We looked through the electronic MEDLINE, EMBASE, Cochrane, and PubMed databases.
Iram Saifi, Shivali Kashikar, Pratapsingh H. Parihar, Gaurav Vedprakash Mishra, Mayur Wanjari   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Off-label prescriptions in diabetic foot

Jornal Vascular Brasileiro, 2014
Prescription of a drug outside of the indications for which it was originally approved by regulators is internationally known as "off-label" prescription.
Luís Jesuíno de Oliveira Andrade, Larissa Santos França, Paulo Roberto Santana de Melo, Marcelo Araújo   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Subject Analysis, Subject heading principles.ppt

Consists of 12 PowerPoint presentations created for a course in subject analysis taught at Charles University, Prague, in 2005. Topics covered include subject heading construction, classification, shelf listing, and subject authority work, with emphasis
Sapon-White, Richard
core   +6 more sources

The words of prevention, part I: changing the model

Revista Brasileira de Medicina de Família e Comunidade, 2015
Objective: this part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain.
Marc Jamoulle, Enrique Gavilán, Raquel Vaz Cardoso, María Ana Mariño, Miguel Pizzanelli   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Critical Review of Medical Humanities Education Curriculum Development Based on Kern’s Curriculum Development Model [PDF]

, 2020
Medical humanities education (MHE) is as essential as basic medical sciences and clinical medicine education. Despite the importance of MHE, MHE curriculum development (CD) has proven to be challenging.
Korean Medical Education Review (의학교육논단)
core   +1 more source

Interrelationship between thyroid hormones and reduced renal function, a review article

Thyroid Research
Background Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications for managing patients with both thyroid and kidney dysfunction.
Sadaf Agahi, Atieh Amouzegar, Mohammadjavad Honarvar, Fereidoun Azizi, Ladan Mehran   +4 more
doaj   +1 more source