Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
A tendency coefficient-driven Pythagorean fuzzy distance approach for selection problems in higher education and medical waste management. [PDF]
Ejegwa PA +4 more
europepmc +1 more source
ABSTRACT In this study, saponification variables were optimized using a face‐centred central composite design‐response surface methodology. The variables included reaction temperature (50°C–120°C), reaction time (30–180 min), KOH concentration (0.5–3 M) and pyrogallol concentration (0–1% w/v).
Milad Kazemi +4 more
wiley +1 more source
The impact of an educational program on the electronic waste management knowledge and practices of dental interns: an interventional study. [PDF]
Galal RS +4 more
europepmc +1 more source
ABSTRACT Healthcare derived polystyrene waste represents a growing and under addressed fraction of plastic waste streams due to contamination risks and limited recyclability. This study aims to investigate the valorization of waste polystyrene foam through catalytic and noncatalytic pyrolysis pathways to evaluate product yield distribution and identify
Salman Khan +4 more
wiley +1 more source
Sustainability in Injectable Drug Delivery Devices: A Systematic Literature Review of Environmental, Economic, and Public Health Impacts. [PDF]
Borrelli EP +5 more
europepmc +1 more source
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley +1 more source
Expanding Waste Segregation Initiatives to Reduce Regulated Medical Waste: A Multi-Departmental Quality Improvement Project. [PDF]
Su EM +5 more
europepmc +1 more source
Sustainable Manufacturing Platforms for Closed‐Cycle Bioeconomy Applications
ABSTRACT The transition to a circular bioeconomy requires innovative production platforms that prioritize sustainability, resource efficiency, and waste minimization. Organic waste from agriculture, aquaculture, and food production represents an underutilized feedstock for biomanufacturing, contributing to a circular economy.
Yelizaveta Chernysh +2 more
wiley +1 more source
Economic burden and patient-related determinants of medication waste in Saudi Arabia: evaluating re-dispensing initiatives for resource optimization. [PDF]
Alsheikh MY +7 more
europepmc +1 more source

