Results 91 to 100 of about 534,265 (348)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Are people with schizophrenia adherent to diabetes medication? A comparative meta-analysis [PDF]

, 2017
Individuals living with schizophrenia are 2-3 times more likely to experience type 2 diabetes mellitus. Diabetes medication adherence is essential to reduce morbidity and mortality in this population.
Firth, Joseph, Gorczynski, Paul, Rosenbaum, Simon, Stubbs, Brendon, Vancampfort, Davy   +4 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

In what way do Nepalese cultural factors affect adherence to antiretroviral treatment in Nepal? [PDF]

, 2011
Individuals’ self administration of medication is an essential component of disease management because incorrect and incomplete medication can result in increased morbidity, mortality and healthcare costs and also spreads drug resistance.
Randall, Julian, Simkhada, Padam, van Teijlingen, Edwin, Wasti, Sharada Prasad   +3 more
core  

Cross-cultural validation and psychometric evaluation of the Self-Medication Assessment Tool (SMAT) for assessing and optimizing medication therapy management of older people [PDF]

, 2018
Background, rationale and objectives: The assessment of medication management ability in the elderly can be performed using specific tools, such as the Self-Medication Assessment Tool, which considers real and simulated regimens.
Advinha, Ana Margarida, de Barros, Carla Teixeria, de Oliveira-Martins, Sofia, Guerreiro, Maria Pereira, Lopes, Manuel José, Nunes, Carla   +5 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Factors Affecting Immunosuppressive Medication Adherence in Liver Transplant Recipients with Poor Adherence: A Qualitative Study

Patient Preference and Adherence, 2023
Zeliha Ozdemir Koken,1 Rana Elcin Sezer Ceren,1 Sabri Karahan,2 Osman Abbasoglu3 1Surgical Nursing Department, Hacettepe University Faculty of Nursing, Ankara, Turkiye; 2Surgical Nursing Department, Harran University, Faculty of Health Science, Sanliurfa,
Ozdemir Koken Z, Sezer Ceren RE, Karahan S, Abbasoglu O   +3 more
doaj  

Relations between cognitive status and medication adherence in patients treated for memory disorders. [PDF]

, 2012
Medication adherence has been increasingly recognized as an important factor in elderly persons\u27 health. Various studies have shown that medication non-adherence is associated with poor health status in this population.
Czaja, Sara J, Hertzog, Christopher, Ownby, Raymond L   +2 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Non-Adherence to Medication in Outpatient Setting in Nigeria: The Effect of Employment Status [PDF]

, 2014
Background: Non-adherence to prescribed medication and health regimen has been identified as responsible for poor health outcomes. This study investigates the reasons for medication non-adherence in outpatient setting among malaria patients in Nigeria.
Okuboyejo, Sena
core   +1 more source