Results 71 to 80 of about 240,410 (292)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Four-year stability of anthropometric and cardio-metabolic parameters in a prospective cohort of older adults [PDF]

, 2015
Aim: To examine the medium-term stability of anthropometric and cardio-metabolic parameters in the general population. Materials & methods: Participants were 5160 men and women from the English Longitudinal Study of Ageing (age ≥50 years) assessed in ...
Beeken, RJ, Gunter, MJ, Jackson, SE, Steptoe, A, van Jaarsveld, CH, Wardle, J   +5 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Trends in dispensing errors reported in Finnish community pharmacies in 2015–2020: a national retrospective register-based study

BMC Primary Care
Background Community pharmacies are responsible for dispensing of medicines and related counselling in outpatient care. Dispensing practices have remarkably changed over time, but little is known about how the changes have influenced medication safety ...
Emilia Mäkinen, Anna-Riia Holmström, Marja Airaksinen, Anna Schoultz   +3 more
doaj   +1 more source

Medical Errors [PDF]

, 2011
Overview: Time of Death: 5:07 p.m. – Proceeding the solemn afternoon of February 22nd 2003, the Santillian family listened on as doctors told them that their cherished loved one was officially pronounced brain dead and would soon have to be taken off ...
Spall, Jennifer
core   +1 more source

Cardiovascular disease behavioral risk factors among Latinos by citizenship and documentation status. [PDF]

, 2020
BACKGROUND:Studies have observed that recent Latino immigrants tend to have a physical health advantage compared to immigrants who have been in the US for many years or Latinos who are born in the United States.
Alberto, Cinthya K, Bustamante, Arturo Vargas, Langellier, Brent A, Ortega, Alexander N, Pintor, Jessie Kemmick, Prelip, Michael L, Wallace, Steven P, Young, Maria-Elena De Trinidad   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Nurses’ Perspectives on Causes of Medication Errors and Non- Reporting at ED.

نشریه پرستاری ایران, 2012
Background & Aims: Medication errors caused by healthcare providers can seriously threat patients' health. The first step to present strategies for preventing such incidents is to assess the causes of errors and non- reporting.
Salavati S, Hatamvand F, Tabesh H, Salehi nasab M   +3 more
doaj  

Understanding patient safety performance and educational needs using the ‘Safety-II’ approach for complex systems [PDF]

, 2016
Participation in projects to improve patient safety is a key component of general practice (GP) specialty training, appraisal and revalidation. Patient safety training priorities for GPs at all career stages are described in the Royal College of General ...
Bowie, Paul, McNab, Duncan, Morrison, Jill, Ross, Alastair   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source