Results 81 to 90 of about 88,182,083 (298)

The Genomics of Opioid Addiction Longitudinal Study (GOALS): study design for a prospective evaluation of genetic and non-genetic factors for development of and recovery from opioid use disorder

BMC Medical Genomics, 2021
Background The opioid use disorder and overdose crisis in the United States affects public health as well as social and economic welfare. While several genetic and non-genetic risk factors for opioid use disorder have been identified, many of the genetic
Jessica Heil, Stefan Zajic, Emily Albertson, Andrew Brangan, Iris Jones, Wendy Roberts, Michael Sabia, Elliot Bodofsky, Alissa Resch, Rachel Rafeq, Rachel Haroz, Russell Buono, Thomas N. Ferraro, Laura Scheinfeldt, Matthew Salzman, Kaitlan Baston   +15 more
doaj   +1 more source

Availability of Medications for Opioid Use Disorder in Opioid Treatment Programs

JAMA Network Open
ImportanceAs the primary facilities authorized to dispense methadone, opioid treatment programs (OTPs) are a critical access point for medications for opioid use disorder (MOUD). However, research is limited on the extent to which OTPs offer a broad range of MOUD and on the characteristics of programs that provide more comprehensive medication ...
Lindenfeld, Zoe, Cantor, Jonathan H., Mauri, Amanda I., Bandara, Sachini, Suryavanshi, Aarya, Krawczyk, Noa   +5 more
openaire   +2 more sources

Cerebrospinal Fluid Cytokine Expression and Relationships With Neurological Measures in Virologically Controlled People With HIV

Annals of Neurology, EarlyView.
Objective Quantify cytokines in cerebrospinal fluid (CSF) of virologically suppressed people with HIV (PWH) and people without HIV (PWoH) and correlate these with neuroimaging, neuropsychometric (NP), and neurodegenerative measurements. Methods CSF samples were collected from virologically suppressed PWH and demographically matched PWoH under a natural
Jack Peterson, Clarissa Xia, Govind Nair, Joseph Snow, Julia Stone, Gina Norato, Brandon Do, Samuel Darko, Kory Johnson, Swati Shah, Amanda Wiebold, Melina Jones, Avindra Nath, Darshan Pandya   +13 more
wiley   +1 more source

Medication-Based Treatment for Opioid Use Disorder: A Look at Mortality and Utilization

, 2023
Purpose: The purpose of this article is to review opioid use disorder (OUD), medication-based treatment (MAT) options, and the effects on mortality.
Carpenter, Sarah
core   +1 more source

Use of Medications for Opioid Use Disorder in Older Adults

American Journal of Preventive Medicine
The American population diagnosed with opioid use disorder is growing, particularly those aged ≥65 years. Less than 30% of opioid use disorder patients receive medication for opioid use disorder, and even fewer older adults.Using 20% national Medicare data, beneficiaries aged over 65 years diagnosed with opioid use disorder in 2017-2022 were selected ...
Yong-Fang Kuo, Jordan Westra, Edythe P. Harvey, Mukaila A. Raji   +3 more
openaire   +2 more sources

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Infectious disease complications associated with opioid use disorder at a southern county hospital: a retrospective chart review

BMC Infectious Diseases
Background Injection drug-use (IDU) is related to significant morbidity and mortality. Recent studies of IDU-associated infections have primarily focused on regions outside of the southern US.
Harini Balakrishnan, Nicholas Campalans, Kapila Marambage, Joan Reisch, Ank E. Nijhawan   +4 more
doaj   +1 more source

Reduced emergency department use among insured individuals receiving extended-release buprenorphine in a health system setting

Drug and Alcohol Dependence Reports
Introduction: Extended-release buprenorphine (XR-Bup) is associated with reduced opioid use and opioid negative urine drug screens. Little is known about its use in outpatient addiction care provided within health systems. Methods: Individuals prescribed
Bobbi Jo H. Yarborough, Scott P. Stumbo, Shannon L. Janoff, Erin M. Keast, Michael C. Leo, Sarah J. Leitz   +5 more
doaj   +1 more source

The Inclusion of Patients’ Reported Outcomes to Inform Treatment Effectiveness Measures in Opioid Use Disorder. A Systematic Review

Patient Related Outcome Measures, 2022
Nitika Sanger,1,* Balpreet Panesar,2,* Michael Dennis,3 Tea Rosic,4 Myanca Rodrigues,4 Elizabeth Lovell,5 Shuling Yang,3 Mehreen Butt,6 Lehana Thabane,4,7 Zainab Samaan4,5 1Medical Science Graduate Program, McMaster University, Hamilton, Ontario,
Sanger N, Panesar B, Dennis M, Rosic T, Rodrigues M, Lovell E, Yang S, Butt M, Thabane L, Samaan Z   +9 more
doaj