Results 91 to 100 of about 2,729,044 (237)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Contributors to prescribing challenges and medication safety.

, 2022
Contributors to prescribing challenges and medication safety.
Darren M. Ashcroft (7359257), Richard N. Keers (5900339), James Dunlop (5524721), Aseel S. Abuzour (14053917), Petra Brown (5900534), Esnath Magola-Makina (14053914)   +5 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Safermeds Survey Report

, 2016
The national medication safety programme “safermeds” will work with patients, healthcare professionals and healthcare organisations to reduce patient harm associated with medicines or their omission.
National Medication Safety Programme
core  

People with insomnia: experiences with sedative hypnotics and risk perception [PDF]

, 2016
Background - Sedative hypnotics form an important part of managing insomnia and are recommended for short-term use. It is standard practice for clinicians to inform the patient to use medications only ‘when required’, but the use of these medications is ...
Saini, Bandana, Delwyn J. Bartlett, Bartlett, Delwyn, Janet M. Y. Cheung, Ellis, Jason, Bandana Saini, Jason G. Ellis, Cheung, Janet, Armour, Carol, Carol L. Armour   +9 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A lightweight GhostYOLO framework with GhostDynamic Module and multi-scale attention for thyroid nodule diagnosis

Scientific Reports
Ultrasound is the primary tool for thyroid nodule assessment, but diagnostic accuracy and efficiency require improvement. This study aims to develop a high-performance, computationally efficient deep learning model for thyroid nodule detection.
Dianhuan Tan, Chen Cheng, Tingting Zheng, Desheng Sun   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Photo coding: a pragmatic approach to measuring intervention fidelity in a pharmacy system re-design

Implementation Science Communications
Background Measuring intervention fidelity can help justify the transition of evidence-based practices into everyday community-based practices by helping identify components of the intervention supporting the intervention’s uptake.
Stephanie M. Resendiz, Shiying Mai, Aaron M. Gilson, Jamie A. Stone, Emily L. Hoffins, Jason S. Chladek, Taylor L. Watterson, Katherine G. Moore, Michelle A. Chui   +8 more
doaj   +1 more source