Results 91 to 100 of about 789,890 (303)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Contributing to a “culture of safety” by increasing usage of the drug library on smart infusion pumps: A Quality Improvement Project [PDF]

, 2015
Background: Computerized infusion devices called smart infusion pumps or smart pumps are clinical tools capable of decreasing IV medication infusion calculation errors through the use of embedded drug libraries.
Armstrong, Heidi
core   +1 more source

Medication Risk and Polypharmacy in Minority Older Adults [PDF]

, 2020
Medication Risk and Polypharmacy in Minority Older Adults Rusha Patel, Depts. of Biology and Chemistry, with Dr. Youssef Roman, VCU School of Pharmacy, Dr. Elvin Price, VCU School of Pharmacy, and Dr.
Patel, Rusha
core   +1 more source

Characteristics of drug and dietary supplement inquiries by college athletes. [PDF]

, 2010
BackgroundIn the United States, the National Center for Drug Free Sport manages the drug-testing programs for athletes of the National Collegiate Athletic Association (NCAA).
Ambrose, Peter J, Olander, Rachel, Tsourounis, Candy, Uryasz, Frank   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Photo coding: a pragmatic approach to measuring intervention fidelity in a pharmacy system re-design

Implementation Science Communications
Background Measuring intervention fidelity can help justify the transition of evidence-based practices into everyday community-based practices by helping identify components of the intervention supporting the intervention’s uptake.
Stephanie M. Resendiz, Shiying Mai, Aaron M. Gilson, Jamie A. Stone, Emily L. Hoffins, Jason S. Chladek, Taylor L. Watterson, Katherine G. Moore, Michelle A. Chui   +8 more
doaj   +1 more source

Navigating Independent Double Checks for Safer Care: A Nursing Perspective [PDF]

, 2015
The purpose of this study was to explore registered nurses’ understanding and practice of “independent double-checks” prior to administration of high-alert medications. The study used a qualitative descriptive design for data collection and data analysis.
Grant, Danielle D
core   +1 more source

Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children (Review) [PDF]

, 2009
Background Traditionally inhaled treatment for asthma has been considered as preventer and reliever therapy. The combination of formoterol and budesonide in a single inhaler introduces the possibility of using a single inhaler for both prevention and ...
Adams, Balanzat, Bateman, Berggren, Bisgaard, Bisgaard, Bleecker, Bousquet, Bruce, Buhl, Buhl, Cates, Cates Christopher, D'Urzo, Greenstone, Haahtela, Haahtela, Higgins, Higgins, Ind, Jenkins, Johansson, Jonkers, Kuna, Kuna, Lasserson, Loukides, Lundborg, Ni Chroinin, O'Byrne, O'Byrne, O'Byrne, O'Byrne, O'Byrne, O'Byrne, Palmqvist, Price, Price, Rabe, Rabe, Rabe, Richter, Scicchitano, Sears, Sovani, Tattersfield, Tattersfield, Vogelmeier, Vogelmeier, Vogelmeier, Walters   +50 more
core   +1 more source