Results 101 to 110 of about 4,247,513 (344)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Unplanned medication discontinuation as a potential pharmacovigilance signal : a nested young person cohort study [PDF]

, 2014
Because of relatively small treatment numbers together with low adverse drug reaction (ADR) reporting rates the timely identification of ADRs affecting children and young people is problematic.
Marion Bennie, Helms, Peter John, Angela Peichen Sun, Kirby, Bradley, James Stuart McLay, Black, Corri, Bennie, Marion, Bradley Kirby, Sun, Angela Peichen, Corri Black, Peter John Helms, McLay, James Stuart   +11 more
core   +1 more source

Percepción de la administración segura de medicamentos en atención primaria

Atención Primaria, 2022
Resumen: Objetivo: El propósito de este estudio fue conocer la percepción de enfermeras sobre la seguridad en la preparación y administración de medicamentos en un departamento de salud de atención primaria del Sistema Nacional de Salud de España ...
Francisco Miguel Escandell Rico, Lucía Pérez Fernández   +1 more
doaj   +1 more source

Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations

Annals of Neurology, 2022
This study was undertaken to examine the comparative safety of antiseizure medication (ASM) monotherapy in pregnancy with respect to risk of major congenital malformations (MCMs), overall and by MCM subtype.
Jacqueline M. Cohen, S. Alvestad, C. Cesta, M. Bjørk, M. Leinonen, M. Nørgaard, Kristjana Einarsdóttir, A. Engeland, M. Gissler, Ø. Karlstad, K. Klungsøyr, I. Odsbu, J. Reutfors, R. Selmer, T. Tomson, S. P. Ulrichsen, H. Zoega, K. Furu   +17 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Post hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial [PDF]

, 2014
David R Coghill,1 Tobias Banaschewski,2 Michel Lecendreux,3 César Soutullo,4 Alessandro Zuddas,5 Ben Adeyi,6 Shaw Sorooshian7 1Division of Neuroscience, University of Dundee, Dundee, UK; 2Child and Adolescent Psychiatry and Psychotherapy, Central
Banaschewski T, Sorooshian S, Sorooshian, Shaw, Coghill DR, Lecendreux M, Coghill, DR, Soutullo, C, Soutullo, César, Banaschewski, Tobias, SOROOSHIAN S., Banaschewski, T, Adeyi, B, Coghill, David R., Zuddas, Alessandro, Adeyi B, Adeyi, Ben, Sorooshian, S, Zuddas A, Zuddas, A, Lecendreux, Michel, Lecendreux, M, Soutullo C   +21 more
core   +1 more source

Pharmacovigilance system in Saudi Arabia

Saudi Pharmaceutical Journal, 2017
Pharmacovigilance plays an important role in ensuring that patients are receiving safe drugs. In Saudi Arabia, Saudi Food and Drug Authority, health institutions, marketing authorization holders and healthcare professional are involved in ...
Thamir M. Alshammari, Mohammed Alshakka, Hisham Aljadhey   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Collaboratively planning for medicines administration: a survey evaluation

, 2011
Aims This survey evaluated the experiences of mental health nurses who had undergone assessment of their competence in the administration of medicines using established assessment frameworks.
Smith, George, Rebecca, Burgess-Dawson, Dewhirst, Kate, GEORGE SMITH, Hemingway, Steve, REBECCA BURGESS-DAWSON, Baxter, Hazel, Burgess-Dawson, Rebecca, STEVE HEMINGWAY, HAZEL BAXTER, KATE DEWHIRST   +10 more
core   +1 more source