Results 131 to 140 of about 199,052 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quality Improvement: Outcomes of Huddle Education for Titratable Sedating Medications [paper]

, 2019
Background: Nurses have a profound responsibility to act in the best interest of their patients. One way they care for their patients responsibly in the critical care setting is by routinely assessing and administering medications according to the ...
Ee, Alisa
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The challenge of developing pain medications for children: therapeutic needs and future perspectives

, 2019
Mariëlle Eerdekens,1 Christoph Beuter,1 Claudia Lefeber,1 John van den Anker2,31Grünenthal GmbH, Aachen, Germany; 2Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children’s Hospital, Basel, Switzerland ...
Eerdekens M, Lefeber C, van den Anker J, Beuter C   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Medication adherence in chronic illness: do beliefs about medications play a role?

, 2018
Jacinthe Lemay,1 Mohammad Waheedi,2 Sarah Al-Sharqawi,1 Tania Bayoud2 1Department of Pharmacology and Therapeutics, 2Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Safat, Kuwait Background: Several medicines are prescribed for
Waheedi M, Lemay J, Al-Sharqawi S, Bayoud T   +3 more
core  

Navigating Pregnancy Testing in Chronic Pain Management for Women of Reproductive Age

Journal of Pain Research
Shoran Tamura,1 Swarnima Vardhan,2 Kathryn Breidenbach,3 Naum Shaparin,3 Amaresh Vydyanathan,3 Karina Gritsenko3 1Department of Anesthesiology, Columbia University, New York, NY, USA; 2Department of Anesthesiology, Yale New Haven Health/Bridgeport ...
Tamura S, Vardhan S, Breidenbach K, Shaparin N, Vydyanathan A, Gritsenko K   +5 more
doaj  

ON CRIMINAL LIABILITY FOR ADULTERATED MEDICATIONS

Russian Journal of Economics and Law, 2011
Having studied the circulation of adulterrated medications in Russia, the author has stated that in prractice these actions are qualified by the Russian Criminal Code not uniformly, and grounded including into the Russian Crimianal Code of the Artice 238.
Y. Klyushkina
doaj  

Type 1 Narcolepsy in Pregnancy: A Case Report and Review of Literature

American Journal of Perinatology Reports
Background Type 1 narcolepsy (with cataplexy) is a rare disorder affecting the central nervous system and is characterized by the inability to control sleep–wake cycles. There is a paucity of data regarding management during pregnancy.
Asnat Yuabov, Alexandra Kilinsky, Dina El Kady   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source