Results 71 to 80 of about 388,773 (268)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Use of Isihlambezo in the Upper Tugela Region
South African Family Practice, 1991 No abstract available.
Gary Morris, B.E. Mdlalose
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Revista de Investigación Agraria y Ambiental, 2015 El sauco Sambucus nigra es un arbusto con características botanicas, composicion quimica y sustancias activas, que ofrece las condiciones para ser aprovechado con fines medicinales, alimenticios, ornamentales, artesanales y para suplementación animal ...
Beatriz Milena Grajales Atehortúa +2 more
doaj +1 more source
No medicine is sometimes the best medicine [PDF]
BMJ Case Reports, 2015 A 76-year-old woman was admitted to hospital from the rheumatology outpatient clinic for investigation of fatigue, malaise, emotional lability, muscle weakness, productive cough and postural hypotension. She had been taking prednisone 60–40 mg daily for 6 weeks for suspected giant cell arteritis, along with six other regular medications, and had ...
openaire +5 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
PharmaceuticalsBackground/Objectives: The species Mikania glomerata and Mikania laevigata are commonly referred to as guaco. Their preparations are used in traditional Brazilian medicine, mainly to address respiratory conditions affecting the upper airways. Considering
Thaís Pelegrin Garcia +6 more
doaj +1 more source