Results 171 to 180 of about 1,538,508 (356)
From Patterns to Pills: How Informatics Is Shaping Medicinal Chemistry. [PDF]
PharmaceuticsTrachtenberg A, Akabayov B.
europepmc +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry? [PDF]
ACS Med Chem LettVeale CGL, Edkins AL.
europepmc +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) [PDF]
, 2007 Anita Brinker +3 more
openalex +1 more source