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Furazans in Medicinal Chemistry
Journal of Medicinal Chemistry, 2021Incorporation of heterocycles into drug molecules can enhance physical properties and biological activity. A variety of heterocyclic groups is available to medicinal chemists, many of which have been reviewed in detail elsewhere. Oxadiazoles are a class of heterocycle containing one oxygen and two nitrogen atoms, available in three isomeric forms ...
Ross S. Mancini +3 more
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Oxadiazoles in Medicinal Chemistry
Journal of Medicinal Chemistry, 2012Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities.
Jonas, Boström +4 more
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Medicinal Chemistry of Aminocyclitols
Current Medicinal Chemistry, 2010Aminocyclitols comprise an important group of compounds with remarkable biological activities. From a structural standpoint, aminocyclitols are amino polyhydroxy cycloalkanes that can be found in nature in several families of natural products. Among them, the aminoglycoside antibiotics, since the discovery of streptomycin, have become particularly ...
Díaz-Bueno, Lucía +1 more
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Drug Discovery Today, 2006
With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved
Marcus, Koppitz, Knut, Eis
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With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved
Marcus, Koppitz, Knut, Eis
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The Medicinal Chemistry of Peptides
Current Medicinal Chemistry, 2009The shortcomings of native peptides as pharmaceuticals have been long known: short duration of action, lack of receptor selectivity, lack of oral bioavailability. However medicinal chemistry offers solutions to the first two limitations and oral bioavailability issues have been addressed with novel routes of administration (e.g. intranasal, inhalation)
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Macromolecular Chemistry and Medicine
Angewandte Chemie International Edition in English, 1970AbstractMacromolecular substances are used in medicine both as materials and as reagents. In the former category polymers serve as replacements for soft tissue, as cardiovascular and orthopedic implants, and as adhesives. When employed as reagents, macromolecules interact with living tissue and play an active part in bodily repair processes.
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Proteomics in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry, 2006Proteomics is becoming an important research area for studying protein expression patterns induced by different external stimuli. An important aspect of proteomics is to identify and quantify proteins. Many new technologies and techniques have been developed in this field and have been applied to various aspects of drug discovery.
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Automation in Medicinal Chemistry
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Fluorine in Medicinal Chemistry
ChemBioChem, 2004AbstractFluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicinal chemistry. Quite often, fluorine is introduced to improve the metabolic stability by blocking
Hans-Joachim, Böhm +7 more
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Fluorine in Medicinal Chemistry
2015Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and ...
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